Search Results

Overview

Uniprot ID	Q5VYK3
Protein Name	Proteasome adapter and scaffold protein ECM29
Gene Name	ECPAS
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1039	LMTGKRVKHEVSGET
1067	GQGLSTYKELCSLAS
313	YLGDIPLKTKEGAVL
315	GDIPLKTKEGAVLKP

Function

Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity)

Protein Sequence

10 MAAAAASASQ 20 DELNQLERVF 30 LRLGHAETDE 40 QLQNIISKFL 50 PPVLLKLSST 60 QEGVRKKVME 70 LLVHLNKRIK 80 SRPKIQLPVE 90 TLLVQYQDPA 100 AVSFVTNFTI 110 IYVKMGYPRL 120 PVEKQCELAP 130 TLLTAMEGKP 140 QPQQDSLMHL 150 LIPTLFHMKY 160 PVESSKSASP 170 FNLAEKPKTV 180 QLLLDFMLDV 190 LLMPYGYVLN 200 ESQSRQNSSS 210 AQGSSSNSGG 220 GSGIPQPPPG 230 MSFYAAKRVI 240 GDNPWTPEQL 250 EQCKLGIVKF 260 IEAEQVPELE 270 AVLHLVIASS 280 DTRHSVATAA 290 DLELKSKQSL 300 IDWNNPAIIN 310 KMYKVYLGDI 320 PLKTKEGAVL 330 KPELKRDPVS 340 TRVKLKIVPH 350 LLRSRQAAET 360 FPANIQVVYD 370 GLFGTNTNSK 380 LRTLSLQFVH 390 HICITCPEIK 400 IKPLGPMLLN 410 GLTKLINEYK 420 EDPKLLSMAY 430 SAVGKLSSRM 440 PHLFTKDIAL 450 VQQLFEALCK 460 EEPETRLAIQ 470 EALSMMVGAY 480 STLEGAQRTL 490 MEALVASYLI 500 KPEVQVRQVA 510 VKFASTVFPS 520 DHIPSRYLLL 530 LAAGDPREEV 540 HGEAQRVLRC 550 LPGRNRKEST 560 SEQMPSFPEM 570 VYYIQEKASH 580 RMKTPVKYMT 590 GTTVLPFNPA 600 AFGEIVLYLR 610 MCLAHSAGVV 620 PTSQSLADMQ 630 DHAPAIGRYI 640 RTLMSSGQMA 650 PSSSNKSGET 660 NPVQIYIGLL 670 QQLLAGVGGL 680 PVMYCLLEAV 690 SVYPEKLATK 700 FVDKTEWIKS 710 LMNNSKEEMR 720 ELAALFYSVV 730 VSTVSGNELK 740 SMIEQLIKTT 750 KDNHSPEIQH 760 GSLLALGFTV 770 GRYLAKKKMR 780 MSEQQDLERN 790 ADTLPDQEEL 800 IQSATETIGS 810 FLDSTSPLLA 820 IAACTALGEI 830 GRNGPLPIPS 840 EGSGFTKLHL 850 VESLLSRIPS 860 SKETNKMKER 870 AIQTLGYFPV 880 GDGDFPHQKL 890 LLQGLMDSVE 900 AKQIELQFTI 910 GEAITSAAIG 920 TSSVAARDAW 930 QMTEEEYTPP 940 AGAKVNDVVP 950 WVLDVILNKH 960 IISPNPHVRQ 970 AACIWLLSLV 980 RKLSTHKEVK 990 SHLKEIQSAF 1000 VSVLSENDEL 1010 SQDVASKGLG 1020 LVYELGNEQD 1030 QQELVSTLVE 1040 TLMTGKRVKH 1050 EVSGETVVFQ 1060 GGALGKTPDG 1070 QGLSTYKELC 1080 SLASDLSQPD 1090 LVYKFMNLAN 1100 HHAMWNSRKG 1110 AAFGFNVIAT 1120 RAGEQLAPFL 1130 PQLVPRLYRY 1140 QFDPNLGIRQ 1150 AMTSIWNALV 1160 TDKSMVDKYL 1170 KEILQDLVKN 1180 LTSNMWRVRE 1190 SSCLALNDLL 1200 RGRPLDDIID 1210 KLPEIWETLF 1220 RVQDDIKESV 1230 RKAAELALKT 1240 LSKVCVKMCD 1250 PAKGAAGQRT 1260 IAALLPCLLD 1270 KGMMSTVTEV 1280 RALSINTLVK 1290 ISKSAGAMLK 1300 PHAPKLIPAL 1310 LESLSVLEPQ 1320 VLNYLSLRAT 1330 EQEKAAMDSA 1340 RLSAAKSSPM 1350 METINMCLQY 1360 LDVSVLGELV 1370 PRLCELIRSG 1380 VGLGTKGGCA 1390 SVIVSLTTQC 1400 PQDLTPYSGK 1410 LMSALLSGLT 1420 DRNSVIQKSC 1430 AFAMGHLVRT 1440 SRDSSTEKLL 1450 QKLNGWYMEK 1460 EEPIYKTSCA 1470 LTIHAIGRYS 1480 PDVLKNHAKE 1490 VLPLAFLGMH 1500 EIADEEKSEK 1510 EECNLWTEVW 1520 QENVPGSFGG 1530 IRLYLQELIT 1540 ITQKALQSQS 1550 WKMKAQGAIA 1560 MASIAKQTSS 1570 LVPPYLGMIL 1580 TALLQGLAGR 1590 TWAGKEELLK 1600 AIACVVTACS 1610 AELEKSVPNQ 1620 PSTNEILQAV 1630 LKECSKENVK 1640 YKIVAISCAA 1650 DILKATKEDR 1660 FQEFSNIVIP 1670 LIKKNSLESS 1680 GVRTTKNEEE 1690 NEKEKELQLE 1700 YLLGAFESLG 1710 KAWPRNAETQ 1720 RCYRQELCKL 1730 MCERLKLSTW 1740 KVQLGVLQSM 1750 NAFFQGLMLL 1760 EEEHADPEAL 1770 AEILLETCKS 1780 ITYSLENKTY 1790 SSVRTEALSV 1800 IELLLKKLEE 1810 SKQWECLTSE 1820 CRVLLIESLA 1830 TMEPDSRPEL 1840 QEKAALLKKT LENLE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0030134	COPII-coated ER to Golgi transport vesicle
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0030139	endocytic vesicle
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
Cellular Component	GO:0005770	late endosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005771	multivesicular body
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000502	proteasome complex
Molecular Function	GO:0060090	molecular adaptor activity
Molecular Function	GO:0070628	proteasome binding
Biological Process	GO:0036503	ERAD pathway
Biological Process	GO:0043248	proteasome assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.