Search Results

Overview

Uniprot IDQ5VZ89
Protein NameDENN domain-containing protein 4C
Gene NameDENND4C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1249 LKSPLGSKSSSMELH
1620 SGDVQTMKISSVPNS

Function

Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin

Protein Sequence

10 MIEDKGPRVT 20 DYFVVAGLTD 30 TSTLLDQEIN 40 RLDTKSTGPK 50 APITDIAIII 60 KSAGETVPEG 70 YTCVEATPSA 80 LQANLNYGSL 90 KSPELFLCYK 100 RGRDKPPLTD 110 IGVLYEGKER 120 LIPGCEVILA 130 TPYGRCANVN 140 NSSTTSQRIF 150 ITYRRAPPVR 160 PQNSLAVTDI 170 CVIVTSKGET 180 PPHTFCKVDK 190 NLNCGMWGSS 200 VFLCYKKSVP 210 ASNAIAYKAG 220 LIFRYPEEDY 230 ESFPLSESDV 240 PLFCLPMGAT 250 IECWDPETKY 260 PLPVFSTFVL 270 TGSSAKKVYG 280 AAIQFYEPYS 290 RELLSEKQLM 300 HLGLLTPVER 310 KMVSKSINTN 320 KCICLLSHWP 330 FFEAFRKFLM 340 FIYKLSVSGP 350 HPLPIEKHIS 360 HFMQNIPFPS 370 PQRPRILVQL 380 SVHDALILSQ 390 PVSTPLPLSG 400 ANFSTLLMNL 410 GPENCATLLL 420 FVLLESKILL 430 HSLRPAVLTG 440 VAEAVVAMIF 450 PFQWQCPYIP 460 LCPLSLAAVL 470 SAPLPFIVGV 480 DSRYFDLHDP 490 PQDVVCIDLD 500 TNMLYVSDEK 510 KNMNWKQLPK 520 KPCKNLLSTL 530 KKLYPQLSSV 540 HQKTQEGSAI 550 DMTPIEADFS 560 WQKKMTQLEM 570 EIQEAFLRFM 580 ASILKGYRTY 590 LRPITEAPSN 600 KATAADSLFD 610 RQGFLKSRDR 620 AYAKFYTLLS 630 KTQIFIRFIE 640 ECSFVSDKDT 650 GLAFFDDCIE 660 KLFPDKGTEK 670 TDKVDFDSAE 680 DTRLIELDDS 690 QKSEHTVFIM 700 PPEPPPDDGK 710 DLSPKYSYKY 720 FPRLDLKLFD 730 RPQELKLCFS 740 RHPTGNSITK 750 SPPLMAKRTK 760 QEIKTAHKLA 770 KRCYTNPPQW 780 AKCLFSHCYS 790 LWFICLPAYV 800 RVSHPKVRAL 810 QQAYDVLIKM 820 RKTDVDPLDE 830 VCYRVVMQLC 840 GLWGHPVLAV 850 RVLFEMKTAR 860 IKPNAITYGY 870 YNKVVLESPW 880 PSSTRSGIFL 890 WTKVRNVVRG 900 LAQFRQPLKK 910 TVQRSQVSSI 920 SGGQSDQGYG 930 SKDELIKDDA 940 EIHVPEEQAA 950 RELITKTKMQ 960 TEEVCDASAI 970 VAKHSQPSPE 980 PHSPTEPPAW 990 GSSIVKVPSG 1000 IFDVNSRKSS 1010 TGSISNVLFS 1020 TQDPVEDAVF 1030 GEATNLKKNG 1040 DRGEKRQKHF 1050 PERSCSFSSE 1060 SRAGMLLKKS 1070 SLDSNSSEMA 1080 IMMGADAKIL 1090 TAALTCPKTS 1100 LLHIARTHSF 1110 ENVSCHLPDS 1120 RTCMSESTWN 1130 PEHRSSPVPE 1140 MLEESQELLE 1150 PVVDDVPKTT 1160 ATVDTYESLL 1170 SDSNSNQSRD 1180 LKTVSKDLRN 1190 KRSSLYGIAK 1200 VVQREDVETG 1210 LDPLSLLATE 1220 CTGGKTPDSE 1230 DKLFSPVIAR 1240 NLADEIESYM 1250 NLKSPLGSKS 1260 SSMELHREEN 1270 RESGMTTAFI 1280 HALERRSSLP 1290 LDHGSPAQEN 1300 PESEKSSPAV 1310 SRSKTFTGRF 1320 KQQTPSRTHK 1330 ERSTSLSALV 1340 RSSPHGSLGS 1350 VVNSLSGLKL 1360 DNILSGPKID 1370 VLKSGMKQAA 1380 TVASKMWVAV 1390 ASAYSYSDDE 1400 EETNRDYSFP 1410 AGLEDHILGE 1420 NISPNTSISG 1430 LVPSELTQSN 1440 TSLGSSSSSG 1450 DVGKLHYPTG 1460 EVPFPRGMKG 1470 QDFEKSDHGS 1480 SQNTSMSSIY 1490 QNCAMEVLMS 1500 SCSQCRACGA 1510 LVYDEEIMAG 1520 WTADDSNLNT 1530 ACPFCKSNFL 1540 PLLNIEFKDL 1550 RGSASFFLKP 1560 STSGDSLQSG 1570 SIPLANESLE 1580 HKPVSSLAEP 1590 DLINFMDFPK 1600 HNQIITEETG 1610 SAVEPSDEIK 1620 RASGDVQTMK 1630 ISSVPNSLSK 1640 RNVSLTRSHS 1650 VGGPLQNIDF 1660 TQRPFHGIST 1670 VSLPNSLQEV 1680 VDPLGKRPNP 1690 PPVSVPYLSP 1700 LVLRKELESL 1710 LENEGDQVIH 1720 TSSFINQHPI 1730 IFWNLVWYFR 1740 RLDLPSNLPG 1750 LILTSEHCNE 1760 GVQLPLSSLS 1770 QDSKLVYIQL 1780 LWDNINLHQE 1790 PREPLYVSWR 1800 NFNSEKKSSL 1810 LSEEQQETST 1820 LVETIRQSIQ 1830 HNNVLKPINL 1840 LSQQMKPGMK 1850 RQRSLYREIL 1860 FLSLVSLGRE 1870 NIDIEAFDNE 1880 YGIAYNSLSS 1890 EILERLQKID 1900 APPSASVEWC RKCFGAPLI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0030659 cytoplasmic vesicle membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0032593 insulin-responsive compartment
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030904 retromer complex
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0015031 protein transport
Biological Process GO:0032483 regulation of Rab protein signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.