Search Results

Overview

Uniprot ID	Q5VZK9
Protein Name	F-actin-uncapping protein LRRC16A
Gene Name	CARMIL1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1066	KKKRDSRKSSGFLNL
1302	ALLPPVLKKVPSDKE
1303	LLPPVLKKVPSDKER

Function

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667)

Protein Sequence

10 MTEESSDVPR 20 ELIESIKDVI 30 GRKIKISVKK 40 KVKLEVKGDK 50 VENKVLVLTS 60 CRAFLVTARI 70 PTKLELTFSY 80 LEIHGVVCSK 90 SAQMIVETEK 100 CSISMKMASP 110 EDVSEVLAHI 120 GTCLRKIFPG 130 LSPVRIMKKV 140 SMEPSERLAS 150 LQALWDSQTV 160 AEQGPCGGFS 170 QMYACVCDWL 180 GFSYREEVQW 190 DVDTIYLTQD 200 TRELNLQDFS 210 HLDHRDLIPI 220 IAALEYNQWF 230 TKLSSKDLKL 240 STDVCEQILR 250 VVSRSNRLEE 260 LVLENAGLRT 270 DFAQKLASAL 280 AHNPNSGLHT 290 INLAGNPLED 300 RGVSSLSIQF 310 AKLPKGLKHL 320 NLSKTSLSPK 330 GVNSLSQSLS 340 ANPLTASTLV 350 HLDLSGNVLR 360 GDDLSHMYNF 370 LAQPNAIVHL 380 DLSNTECSLD 390 MVCGALLRGC 400 LQYLAVLNLS 410 RTVFSHRKGK 420 EVPPSFKQFF 430 SSSLALMHIN 440 LSGTKLSPEP 450 LKALLLGLAC 460 NHNLKGVSLD 470 LSNCELRSGG 480 AQVLEGCIAE 490 IHNITSLDIS 500 DNGLESDLST 510 LIVWLSKNRS 520 IQHLALGKNF 530 NNMKSKNLTP 540 VLDNLVQMIQ 550 DEESPLQSLS 560 LADSKLKTEV 570 TIIINALGSN 580 TSLTKVDISG 590 NGMGDMGAKM 600 LAKALQINTK 610 LRTVIWDKNN 620 ITAQGFQDIA 630 VAMEKNYTLR 640 FMPIPMYDAS 650 QALKTNPEKT 660 EDALQKIENY 670 LLRNHETRKY 680 LQEQAYRLQQ 690 GIVTSTTQQM 700 IDRICVKVQD 710 HLNSLRNCGG 720 DAIQEDLKSA 730 ERLMRDAKNS 740 KTLLPNLYHV 750 GGASWAGASG 760 LLSSPIQETL 770 ESMAGEVTRV 780 VDEQLKALLE 790 SMVDAAENLC 800 PNVMKKAHIR 810 QDLIHASTEK 820 ISIPRTFVKN 830 VLLEQSGIDI 840 LNKISEVKLT 850 VASFLSDRIV 860 DEILDALSHC 870 HHKLADHFSR 880 RGKTLPQQES 890 LEIELAEEKP 900 VKRSIITVEE 910 LTEIERLEDL 920 DTCMMTPKSK 930 RKSIHSRMLR 940 PVSRAFEMEF 950 DLDKALEEVP 960 IHIEDPPFPS 970 LRQEKRSSGF 980 ISELPSEEGK 990 KLEHFTKLRP 1000 KRNKKQQPTQ 1010 AAVCAANIVS 1020 QDGEQNGLMG 1030 RVDEGVDEFF 1040 TKKVTKMDSK 1050 KWSTRGSESH 1060 ELNEGGDEKK 1070 KRDSRKSSGF 1080 LNLIKSRSKS 1090 ERPPTILMTE 1100 EPSSPKGAVR 1110 SPPVDCPRKD 1120 TKAAEHNGNS 1130 ERIEEIKTPD 1140 SFEESQGEEI 1150 GKVERSDSKS 1160 SPQAGRRYGV 1170 QVMGSGLLAE 1180 MKAKQEKRAA 1190 CAQKKLGNDA 1200 VSQDSSSPAL 1210 SGVERSDGGG 1220 AVPKLHPGLP 1230 ENRFGLGTPE 1240 KNTKAEPKAE 1250 AGSRSRSSSS 1260 TPTSPKPLLQ 1270 SPKPSLAARP 1280 VIPQKPRTAS 1290 RPDDIPDSPS 1300 SPKVALLPPV 1310 LKKVPSDKER 1320 DGQSSPQPSP 1330 RTFSQEVSRR 1340 SWGQQAQEYQ 1350 EQKQRSSSKD 1360 GHQGSKSNDS 1370 GEEAEKEFIF V

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031252	cell leading edge
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0031941	filamentous actin
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0044354	macropinosome
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0044877	protein-containing complex binding
Biological Process	GO:0051639	actin filament network formation
Biological Process	GO:0007015	actin filament organization
Biological Process	GO:0051638	barbed-end actin filament uncapping
Biological Process	GO:0016477	cell migration
Biological Process	GO:0030032	lamellipodium assembly
Biological Process	GO:0044351	macropinocytosis
Biological Process	GO:2000813	negative regulation of barbed-end actin filament capping
Biological Process	GO:0030838	positive regulation of actin filament polymerization
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:1902745	positive regulation of lamellipodium organization
Biological Process	GO:0051496	positive regulation of stress fiber assembly
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
Biological Process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation
Biological Process	GO:0031529	ruffle organization
Biological Process	GO:0046415	urate metabolic process

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.