Search Results

Overview

Uniprot IDQ5VZL5
Protein NameZinc finger MYM-type protein 4
Gene NameZMYM4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1180 PRRRGRKKSIVAVEP
1443 PDKLTVGKRKRNEDD
149 FDQVSVFKSIRKDFS
153 SVFKSIRKDFSLVRE
195 KDLDSRLKSSFFDKA
201 LKSSFFDKAANQVEE
350 GCKKILQKGQTAYQR

Function

Required for regulation of cell morphology and cytoskeletal organization

Protein Sequence

10 MAEREVESGP 20 RKRFEQKSGA 30 VFDEIVENCG 40 GIMDTEMSED 50 IDHNLTPTLD 60 SMSYGMPNQT 70 GSENSLLDED 80 DYFLNSGDLA 90 GIPVVGSDNE 100 DEQDFSSKDN 110 LVSSIHTDDS 120 LEVERRVTQH 130 ESDNENEIQI 140 QNKLKKDFPK 150 QFDQVSVFKS 160 IRKDFSLVRE 170 NSKETFSGKE 180 KNRDLTYERE 190 KRLDKPHKDL 200 DSRLKSSFFD 210 KAANQVEETL 220 HTHLPQTPET 230 NFRDSSYPFA 240 NKESIGSELG 250 NSFASNIRIK 260 EEPLDDEYDK 270 AMAPQQGLLD 280 KIKDEPDNAQ 290 EYSHGQQQKT 300 QEGELKISAV 310 FSVSGSPLAP 320 QLTTGFQPSL 330 ASSGMNKMLP 340 SVPATAVRVS 350 CSGCKKILQK 360 GQTAYQRKGS 370 TQLFCSTLCL 380 TGYTVPPARP 390 PPPLTKKTCS 400 SCSKDILNPK 410 DVISAQFENT 420 TTSKDFCSQS 430 CLSTYELKKK 440 PIVTINTNSI 450 STKCSMCQKN 460 AVIRHEVNYQ 470 NVVHKLCSDA 480 CFSKFRSANN 490 LTMNCCENCG 500 GYCYSGSGQC 510 HMLQIEGQSK 520 KFCSSSCITA 530 YKQKSAKITP 540 CALCKSLRSS 550 AEMIENTNSL 560 GKTELFCSVN 570 CLSAYRVKMV 580 TSAGVQVQCN 590 SCKTSAIPQY 600 HLAMSDGSIR 610 NFCSYSCVVA 620 FQNLFNKPTG 630 MNSSVVPLSQ 640 GQVIVSIPTG 650 STVSAGGGST 660 SAVSPTSISS 670 SAAAGLQRLA 680 AQSQHVGFAR 690 SVVKLKCQHC 700 NRLFATKPEL 710 LDYKGKMFQF 720 CGKNCSDEYK 730 KINNVMAMCE 740 YCKIEKIVKE 750 TVRFSGADKS 760 FCSEGCKLLY 770 KHDLAKRWGN 780 HCKMCSYCLQ 790 TSPKLVQNNL 800 GGKVEEFCCE 810 ECMSKYTVLF 820 YQMAKCDACK 830 RQGKLSESLK 840 WRGEMKHFCN 850 LLCILMFCNQ 860 QSVCDPPSQN 870 NAANISMVQA 880 ASAGPPSLRK 890 DSTPVIANVV 900 SLASAPAAQP 910 TVNSNSVLQG 920 AVPTVTAKII 930 GDASTQTDAL 940 KLPPSQPPRL 950 LKNKALLCKP 960 ITQTKATSCK 970 PHTQNKECQT 980 EDTPSQPQII 990 VVPVPVPVFV 1000 PIPLHLYTQY 1010 APVPFGIPVP 1020 MPVPMLIPSS 1030 MDSEDKVTES 1040 IEDIKEKLPT 1050 HPFEADLLEM 1060 AEMIAEDEEK 1070 KTLSQGESQT 1080 SEHELFLDTK 1090 IFEKDQGSTY 1100 SGDLESEAVS 1110 TPHSWEEELN 1120 HYALKSNAVQ 1130 EADSELKQFS 1140 KGETEQDLEA 1150 DFPSDSFDPL 1160 NKGQGIQARS 1170 RTRRRHRDGF 1180 PQPRRRGRKK 1190 SIVAVEPRSL 1200 IQGAFQGCSV 1210 SGMTLKYMYG 1220 VNAWKNWVQW 1230 KNAKEEQGDL 1240 KCGGVEQASS 1250 SPRSDPLGST 1260 QDHALSQESS 1270 EPGCRVRSIK 1280 LKEDILSCTF 1290 AELSLGLCQF 1300 IQEVRRPNGE 1310 KYDPDSILYL 1320 CLGIQQYLFE 1330 NGRIDNIFTE 1340 PYSRFMIELT 1350 KLLKIWEPTI 1360 LPNGYMFSRI 1370 EEEHLWECKQ 1380 LGAYSPIVLL 1390 NTLLFFNTKY 1400 FQLKNVTEHL 1410 KLSFAHVMRR 1420 TRTLKYSTKM 1430 TYLRFFPPLQ 1440 KQESEPDKLT 1450 VGKRKRNEDD 1460 EVPVGVEMAE 1470 NTDNPLRCPV 1480 RLYEFYLSKC 1490 SESVKQRNDV 1500 FYLQPERSCV 1510 PNSPMWYSTF 1520 PIDPGTLDTM 1530 LTRILMVREV 1540 HEELAKAKSE DSDVELSD

Gene Ontology

Classification GO ID Description
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008270 zinc ion binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.