Search Results
Overview
| Uniprot ID | Q5VZY2 |
|---|---|
| Protein Name | Phospholipid phosphatase 4 |
| Gene Name | PLPP4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 77 | KIIRRTDKTEIKEAF |
Function
Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol (PubMed:28851360)
Protein Sequence
10
MRELAIEIGV
20
RALLFGVFVF
30
TEFLDPFQRV
40
IQPEEIWLYK
50
NPLVQSDNIP
60
TRLMFAISFL
70
TPLAVICVVK
80
IIRRTDKTEI
90
KEAFLAVSLA
100
LALNGVCTNT
110
IKLIVGRPRP
120
DFFYRCFPDG
130
VMNSEMHCTG
140
DPDLVSEGRK
150
SFPSIHSSFA
160
FSGLGFTTFY
170
LAGKLHCFTE
180
SGRGKSWRLC
190
AAILPLYCAM
200
MIALSRMCDY
210
KHHWQDSFVG
220
GVIGLIFAYI
230
CYRQHYPPLA
240
NTACHKPYVS
250
LRVPASLKKE
260
ERPTADSAPS
270
LPLEGITEGP
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0000810 | diacylglycerol diphosphate phosphatase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008195 | phosphatidate phosphatase activity |
| Biological Process | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| Biological Process | GO:0046839 | phospholipid dephosphorylation |
| Biological Process | GO:0006644 | phospholipid metabolic process |
| Biological Process | GO:0090279 | regulation of calcium ion import |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.