Search Results

Overview

Uniprot ID	Q5W041
Protein Name	Armadillo repeat-containing protein 3
Gene Name	ARMC3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
14	KEVEPPPKDVFDPLM

Function

Essential for male fertility and sperm motility (By similarity). During spermatogenesis, promotes the autophagic degradation of excessive ribosomes, providing energy resources for mitochondria and thus ensuring sperm flagellar motility (PubMed:34428398)

Protein Sequence

10 MGKKIKKEVE 20 PPPKDVFDPL 30 MIESKKAATV 40 VLMLNSPEEE 50 ILAKACEAIY 60 KFALKGEENK 70 TTLLELGAVE 80 PLTKLLTHED 90 KIVRRNATMI 100 FGILASNNDV 110 KKLLRELDVM 120 NSVIAQLAPE 130 EEVVIHEFAS 140 LCLANMSAEY 150 TSKVQIFEHG 160 GLEPLIRLLS 170 SPDPDVKKNS 180 MECIYNLVQD 190 FQCRAKLQEL 200 NAIPPILDLL 210 KSEYPVIQLL 220 ALKTLGVIAN 230 DKESRTMLRD 240 NQGLDHLIKI 250 LETKELNDLH 260 IEALAVIANC 270 LEDMDTMVQI 280 QQTGGLKKLL 290 SFAENSTIPD 300 IQKNAAKAIT 310 KAAYDPENRK 320 LFHEQEVEKC 330 LVALLGSEND 340 GTKIAASQAI 350 SAMCENSGSK 360 DFFNNQGIPQ 370 LIQLLKSDNE 380 EVREAAALAL 390 ANLTTCNPAN 400 ANAAAEADGI 410 DPLINLLSSK 420 RDGAIANAAT 430 VLTNMAMQEP 440 LRLNIQNHDI 450 MHAIISPLRS 460 ANTVVQSKAA 470 LAVTATACDV 480 EARTELRNSG 490 GLEPLVELLR 500 SKNDEVRKHA 510 SWAVMVCAGD 520 ELTANELCRL 530 GALDILEEVN 540 VSGTRKNKFS 550 EAAYNKLLNN 560 NLSLKYSQTG 570 YLSSSNIIND 580 GFYDYGRINP 590 GTKLLPLKEL 600 CLQEPSDLRA 610 VLLINSKSYV 620 SPPSSMEDKS 630 DVGYGRSISS 640 SSSLRRSSKE 650 KNKKNSYHFS 660 AGFGSPIEDK 670 SEPASGRNTV 680 LSKSATKEKG 690 WRKSKGKKEE 700 EKVKEEEEVM 710 VVPKFVGEGS 720 SDKEWCPPSD 730 PDFSMYVYEV 740 TKSILPITNI 750 KEQIEDLAKY 760 VAEKMGGKIP 770 KEKLPDFSWE 780 LHISELKFQL 790 KSNVIPIGHV 800 KKGIFYHRAL 810 LFKALADRIG 820 IGCSLVRGEY 830 GRAWNEVMLQ 840 NDSRKGVIGG 850 LPAPEMYVID 860 LMFHPGGLMK 870 LRSREADLYR FI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070062	extracellular exosome
Biological Process	GO:0030317	flagellated sperm motility
Biological Process	GO:0034517	ribophagy
Biological Process	GO:0007286	spermatid development

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.