Search Results

Overview

Uniprot IDQ5W0B1
Protein NameORC ubiquitin ligase 1
Gene NameOBI1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
292 SEEDVVSKNQGDSAR
333 ARQESTSKADLNCSK
417 VVQAGGSKKHSNHLR
418 VQAGGSKKHSNHLRK
425 KHSNHLRKLVFDDFC
502 ISSKLSEKSGLCLSK
509 KSGLCLSKRLNSIRS
710 VNQSTKRKIQSSLSS
722 LSSASPSKATKS***

Function

E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578)

Protein Sequence

10 MAQTVQNVTL 20 SLTLPITCHI 30 CLGKVRQPVI 40 CINNHVFCSI 50 CIDLWLKNNS 60 QCPACRVPIT 70 PENPCKEIIG 80 GTSESEPMLS 90 HTVRKHLRKT 100 RLELLHKEYE 110 DEIDCLQKEV 120 EELKSKNLSL 130 ESQIKTILDP 140 LTLVQGNQNE 150 DKHLVTDNPS 160 KINPETVAEW 170 KKKLRTANEI 180 YEKVKDDVDK 190 LKEANKKLKL 200 ENGGLVRENL 210 RLKAEVDNRS 220 PQKFGRFAVA 230 ALQSKVEQYE 240 RETNRLKKAL 250 ERSDKYIEEL 260 ESQVAQLKNS 270 SEEKEAMNSI 280 CQTALSADGK 290 GSKGSEEDVV 300 SKNQGDSARK 310 QPGSSTSSSS 320 HLAKPSSSRL 330 CDTSSARQES 340 TSKADLNCSK 350 NKDLYQEQVE 360 VMLDVTDTSM 370 DTYLEREWGN 380 KPSDCVPYKD 390 EELYDLPAPC 400 TPLSLSCLQL 410 STPENRESSV 420 VQAGGSKKHS 430 NHLRKLVFDD 440 FCDSSNVSNK 450 DSSEDDISRS 460 ENEKKSECFS 470 SPKTGFWDCC 480 STSYAQNLDF 490 ESSEGNTIAN 500 SVGEISSKLS 510 EKSGLCLSKR 520 LNSIRSFEMN 530 RTRTSSEASM 540 DAAYLDKISE 550 LDSMMSESDN 560 SKSPCNNGFK 570 SLDLDGLSKS 580 SQGSEFLEEP 590 DKLEEKTELN 600 LSKGSLTNDQ 610 LENGSEWKPT 620 SFFLLSPSDQ 630 EMNEDFSLHS 640 SSCPVTNEIK 650 PPSCLFQTEF 660 SQGILLSSSH 670 RLFEDQRFGS 680 SLFKMSSEMH 690 SLHNHLQSPW 700 STSFVPEKRN 710 KNVNQSTKRK 720 IQSSLSSASP SKATKS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0004842 ubiquitin-protein transferase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051865 protein autoubiquitination
Biological Process GO:0006513 protein monoubiquitination
Biological Process GO:0006275 regulation of DNA replication

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.