Search Results
Overview
| Uniprot ID | Q5XHX3 |
|---|---|
| Protein Name | Protein enabled homolog |
| Gene Name | Enah |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 417 | RRRRIAEKGSTIETE |
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation
Protein Sequence
10
MDVEFVSYSI
20
PKLRSSQSLR
30
ISEQSICQAR
40
AAVMVYDDAN
50
KKWVPAGGST
60
GFSRVHIYHH
70
TGNNTFRVVG
80
RKIQDHQVVI
90
NCAIPKGLKY
100
NQATQTFHQW
110
RDARQVYGLN
120
FGSKEDANVF
130
ASAMMHALEV
140
LNSQEAGPTL
150
PRQNSQLPAQ
160
VQNGPSQEEM
170
EIQRRQLQEQ
180
QRQKELERER
190
MERERLERER
200
LERERLERER
210
LEQEQLERQR
220
QEREHVERLE
230
RERLERLERE
240
RQDRERERER
250
LEQLEREQVE
260
WERERRMSNA
270
GHVLGPPAPP
280
PPPPLPSGPA
290
YASALPPPPG
300
PPPPPPLPSA
310
GPPPPPPPPP
320
PLPNQVPPPP
330
PPPPAPPLPA
340
SGIFSGSMSE
350
DNRPLTGLAA
360
AIAGAKLRKV
370
SRVEDGSFPS
380
GGNTVSVNLA
390
SSKTDSGRGN
400
GPLPLGGSGL
410
MEEMSALLAR
420
RRRIAEKGST
430
IETEQKEDRS
440
EDAEPVTSKA
450
ASTSTPEPTR
460
KPWERTNTMN
470
GSKSPVISRP
480
KSTPSSQPSA
490
NGVQTEGLDY
500
DRLKQDILDE
510
MRKELAKLKE
520
ELIDAIRQEL
SKSNTA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0001843 | neural tube closure |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.