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Overview

Uniprot ID	Q5XHZ0
Protein Name	Heat shock protein 75 kDa, mitochondrial
Gene Name	Trap1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
111	ARSLYSEKEVFIREL
128	NASDALEKLRHKRVC

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA

Protein Sequence

10 MARELRALLL 20 WGRGLQSALR 30 APALAGVRRG 40 KPVLHLQKTT 50 VHFRDPTQSL 60 ASGISAGQLY 70 STQAAEDKKE 80 EALHSIISNT 90 EAVQGSVSKH 100 EFQAETKKLL 110 DIVARSLYSE 120 KEVFIRELIS 130 NASDALEKLR 140 HKRVCEGQVL 150 PEMEIHLQTD 160 AEKGTITIQD 170 TGIGMTKEEL 180 VSNLGTIARS 190 GSKAFLEALQ 200 HQAETSSRII 210 GQFGVGFYSA 220 FMVADKVEVY 230 SRPAAPESPG 240 YQWLSDGSGV 250 FEIAEASGVR 260 PGTKIIIHLK 270 SDCKDFANES 280 RVQDVVTKYS 290 NFVSFPLYLN 300 GRRINTLQAI 310 WMMDPKDISE 320 FQHEEFYRYI 330 AQAYDKPRFI 340 LHYKTDAPLN 350 IRSIFYVPEM 360 KPSMFDVSRE 370 LGSSVALYSR 380 KVLIQTKATD 390 ILPKWLRFVR 400 GVVDSEDIPL 410 NLSRELLQES 420 ALIRKLRDVL 430 QQRLIKFFID 440 QSKKDAEKYA 450 KFFEDYGLFM 460 REGIVTTAEQ 470 DIKEDIAKLL 480 RYESSALPAG 490 QLTSLSDYAS 500 RMQAGTRNIY 510 YLCAPNRHLA 520 EHSPYYEAMK 530 QKQTEVLFCY 540 EQFDELTLLH 550 LREFDKKKLI 560 SVETDIVVDH 570 YKEEKFEDTS 580 PAGERLSEKE 590 TEELMAWMRN 600 ALGSRVTNVK 610 VTFRLDTHPA 620 MVTVLEMGAA 630 RHFLRMQQLA 640 KTQEERAQLL 650 QPTLEINPRH 660 TLIKKLNQLR 670 EREPELAQLL 680 VDQIYENAMI 690 AAGLVDDPRA 700 MVGRLNDLLV KALERH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Biological Process	GO:1903751	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Biological Process	GO:0006457	protein folding
Biological Process	GO:0009386	translational attenuation
Cellular Component	GO:0005758	mitochondrial intermembrane space
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0140662	ATP-dependent protein folding chaperone
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0051082	unfolded protein binding
Biological Process	GO:1901856	negative regulation of cellular respiration

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.