Search Results

Overview

Uniprot IDQ5XI07
Protein NameLipoma-preferred partner homolog
Gene NameLpp
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
109 QRGNPGGKTLEERRS
177 QPPLTATKKSATKPQ
376 ERLVKNQKVLQNVVD
54 PVVAPKPKYNPYKQP

Function

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus (By similarity)

Protein Sequence

10 MSHPSWLPPR 20 STGEPLGHVP 30 ARMETTHSFG 40 TPSISVSTQQ 50 PPKKFAPVVA 60 PKPKYNPYKQ 70 PGGEGDFLPP 80 PPPPLEDPGT 90 IPSGSGHFPP 100 PPPLDEGAFI 110 VQRGNPGGKT 120 LEERRSSLDA 130 EIDSLTSILA 140 DLECSSPYKP 150 RAPPGSSSSI 160 ASPPVSTPVT 170 GHKRMVIPQQ 180 PPLTATKKSA 190 TKPQAIPIPV 200 TPIGTLKPQP 210 QPVPASYSTA 220 STSSRPAFNV 230 QVKSAQPSTH 240 YMTGSSSGQM 250 YGPGSRSYNT 260 QQVPLSAQCP 270 PPTTCAGTDY 280 AYIPPSGQQA 290 ESGFGYTSNQ 300 GRYFEPFFAA 310 CPSYGGRNEA 320 DPAYGQQVQP 330 NTWKREPGYA 340 APGAGNQNQP 350 GMYSVSGPKK 360 TYITDPVSAP 370 CAPPVQPKER 380 LVKNQKVLQN 390 VVDDRVHGLR 400 KSGFPAPMGP 410 PSVPPSFRPE 420 DELEHLTKKM 430 LYDMENPPAD 440 DYFGRCARCG 450 ENVVGEGTGC 460 TAMDQVFHVD 470 CFTCMVCDIK 480 LRGQPFYAVE 490 KKAYCEPCYI 500 NTLEQCSVCS 510 KPIMERILRA 520 TGKAYHPHCF 530 TCVMCHRSLD 540 GIPFTVDACG 550 LIHCIEDFHK 560 KFAPRCSVCK 570 EPIMPAPGQE 580 ETVRIVALDR 590 DFHVHCYRCE 600 DCGGLLSEGD 610 NQGCYPLDGH 620 ILCKSCNSAR 630 IRVLTAKAST DL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0098609 cell-cell adhesion

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.