Search Results
Overview
| Uniprot ID | Q5XI22 |
|---|---|
| Protein Name | Acetyl-CoA acetyltransferase, cytosolic |
| Gene Name | Acat2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 180 | VSREAQDKVAVVSQN |
| 194 | NRAEHAQKAGHFDKE |
Function
Involved in the biosynthetic pathway of cholesterol
Protein Sequence
10
MNAGSDPVVI
20
ISAARTAIGS
30
FNGALSTVPV
40
HNLGTTVIKE
50
VLQRAKVAPE
60
EVSEVIFGHV
70
LTAGCGQNPT
80
RQASVGAGIP
90
YSVPAWSCQM
100
ICGSGLKAVC
110
LAAQSIAMGD
120
STIVVAGGME
130
NMSKAPHLAH
140
LRSGVKMGEV
150
PLADSILCDG
160
LTDAFHNYHM
170
GITAENVAKK
180
WQVSREAQDK
190
VAVVSQNRAE
200
HAQKAGHFDK
210
EIVPVHVSSR
220
KGLTEVKIDE
230
FPRHGSNLEA
240
MSKLKPYFLT
250
DGTGTVTPAN
260
ASGMNDGAAA
270
VVLMKKTEAE
280
SRMLKPLAQV
290
VSWSQAGVEP
300
SVMGVGPIPA
310
IKQAVAKAGW
320
SLEDVDVFEI
330
NEAFAAVSAA
340
IAKELGLSPE
350
KVNIDGGAIA
360
LGHPLGASGC
370
RILVTLLHTL
380
ERVGGTRGVA
390
ALCIGGGMGI
AMCVQRG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0003985 | acetyl-CoA C-acetyltransferase activity |
| Biological Process | GO:0071398 | cellular response to fatty acid |
| Biological Process | GO:0031670 | cellular response to nutrient |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0033386 | geranylgeranyl diphosphate biosynthetic process |
| Biological Process | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0046952 | ketone body catabolic process |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.