Search Results
Overview
| Uniprot ID | Q5XI68 |
|---|---|
| Protein Name | Protein Dr1 |
| Gene Name | Dr1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 95 | KEVLQECKTVALKRR |
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity)
Protein Sequence
10
MASSSGNDDD
20
LTIPRAAINK
30
MIKETLPNVR
40
VANDARELVV
50
NCCTEFIHLI
60
SSEANEICNK
70
SEKKTISPEH
80
VIQALESLGF
90
GSYISEVKEV
100
LQECKTVALK
110
RRKASSRLEN
120
LGIPEEELLR
130
QQQELFAKAR
140
QQQAELAQQE
150
WLQMQQAAQQ
160
AQLAAASASA
170
SNQAGSSQDE
DDDDDI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0140672 | ATAC complex |
| Cellular Component | GO:0017054 | negative cofactor 2 complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0016251 | RNA polymerase II general transcription initiation factor activity |
| Molecular Function | GO:0017025 | TBP-class protein binding |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0051302 | regulation of cell division |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0090043 | regulation of tubulin deacetylation |
| Biological Process | GO:0051123 | RNA polymerase II preinitiation complex assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.