Search Results
Overview
| Uniprot ID | Q5XIA5 |
|---|---|
| Protein Name | Bifunctional coenzyme A synthase |
| Gene Name | Coasy |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 461 | EMDVAVAKGKTLCVI |
Function
Bifunctional enzyme that catalyzes the fourth step of the coenzyme A biosynthetic pathway, the adenylation of 4'-phosphopantetheine, and the fifth step, the phosphorylation of dephospho-CoA to CoA
Protein Sequence
10
MAVFRSGLLV
20
LTTPLATLAA
30
RLPPILTSAS
40
HLVNHTLYVH
50
LQPGMNLGGP
60
AQPQPSPVQA
70
TFEVLDFITH
80
LYTGADLHRH
90
LDVRILLTNI
100
QTKSTLIPVL
110
SSVQNLAHPP
120
EVVLTDFQTL
130
DGSQYNPVKQ
140
QLERYATSCY
150
SCSPQLSSVL
160
LYPDYGTGEM
170
PLELPNALLP
180
STIRPASPVA
190
RSPRQPVRGY
200
RRGAVGGTFD
210
RLHNAHKVLL
220
SVACVLAQEQ
230
LVVGVADKDL
240
LKSKLLPELL
250
QPYSERVGHL
260
NEFLVDIKPS
270
LTFELIPLLD
280
PYGPAGSDPT
290
LEFLVVSEET
300
YRGGMAVNRF
310
RLENGKEELA
320
LYQIQLLKDQ
330
SHKENEEEKV
340
SSSSFRQRIL
350
GNLLQPPNER
360
PELPSGIYVL
370
GLTGISGSGK
380
SSVAQRLKNL
390
GAYIIDSDHL
400
GHRAYAPGGP
410
AYQPVVEAFG
420
TDILHQDGTI
430
NRKVLGSRVF
440
GNKKQLKMLT
450
DIVWPVIAKL
460
AREEMDVAVA
470
KGKTLCVIDA
480
AMLLEAGWQN
490
MVHEVWTVVI
500
PESEAVRRIV
510
ERDGLSEAAA
520
QSRLQNQMSG
530
QQLVEQSHVV
540
LCTLWESHVT
550
QRQVEKAWDL
560
LQKRLPKAHQ
TRN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004140 | dephospho-CoA kinase activity |
| Molecular Function | GO:0004595 | pantetheine-phosphate adenylyltransferase activity |
| Biological Process | GO:0015937 | coenzyme A biosynthetic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.