Search Results
Overview
| Uniprot ID | Q5XIB1 |
|---|---|
| Protein Name | U5 small nuclear ribonucleoprotein TSSC4 |
| Gene Name | Tssc4 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 292 | TVGFHGSKKRSRDHF |
Function
Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP
Protein Sequence
10
MAETEAGLEV
20
EEPTEDDTLP
30
SDTVSLSDSD
40
SDLSLPSGVE
50
VQALSPERLS
60
GESQEDSGPD
70
DPPSHPTGIP
80
TTAVQPFHLR
90
GMSSTFSQRS
100
HSIFDCLESA
110
ARQEPCSAPQ
120
TSVVDNCSFK
130
RPVAPPSQTP
140
ARSLSRVHGN
150
TDPTRVHPVP
160
DYVSHPERWT
170
KYSLEDVSET
180
SEQSNRDAAL
190
AFLSSRSQAS
200
PTDYVPFFNQ
210
DPSSCGEGRV
220
VFTKPVRGSE
230
ARAERKRVLK
240
KGVVSGAGGE
250
ASVELAHLAG
260
PEAEEWSGHQ
270
GQPEVVVPSE
280
AARPESSSGP
290
IGMKTVGFHG
300
SKKRSRDHFR
310
NRDSNPEGPG
SERGPSV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005682 | U5 snRNP |
| Molecular Function | GO:0140313 | molecular sequestering activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0000387 | spliceosomal snRNP assembly |
| Biological Process | GO:0000244 | spliceosomal tri-snRNP complex assembly |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005681 | spliceosomal complex |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.