Search Results
Overview
| Uniprot ID | Q5XIC0 |
|---|---|
| Protein Name | Enoyl-CoA delta isomerase 2 |
| Gene Name | Eci2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 138 | DGKAQESKGILVTSE |
| 60 | KDPGNEVKLRLYALY |
| 90 | FDFVNKAKWDAWNAL |
Function
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates
Protein Sequence
10
MAAVTWSRAR
20
CWCPSLLQVL
30
RLPVTKLHLG
40
RPAMRATQQD
50
FENAMNQVKL
60
LKKDPGNEVK
70
LRLYALYKQA
80
TEGPCTMPKP
90
GVFDFVNKAK
100
WDAWNALGSL
110
PKETARQNYV
120
DLVSSLSSSS
130
EASSQGKGGA
140
DGKAQESKGI
150
LVTSEGGITK
160
ITFNRPSKKN
170
AITFQMYQDI
180
ILALKNASTD
190
DTVITVFTGA
200
GDYYSSGNDL
210
TNFTSASGGM
220
EEAANKGAIV
230
LREFVNTFID
240
FPKPLVAVVN
250
GPAVGISVTL
260
LGLFDAVYAS
270
DRATFHTPFS
280
HLGQSPEACS
290
SYTFPKMMGS
300
AKAAEMLLFG
310
KKLTAREAWA
320
QGLVTEVFPE
330
STFETEVWTR
340
LKTYAKLPPN
350
SMRISKELIR
360
KNEKEKLHAV
370
NEEECTTLRA
380
RWLSEECINA
390
IMSFVTRKPK
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0004165 | delta(3)-delta(2)-enoyl-CoA isomerase activity |
| Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
| Molecular Function | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds |
| Biological Process | GO:0006635 | fatty acid beta-oxidation |
| Biological Process | GO:0009062 | fatty acid catabolic process |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.