Search Results
Overview
| Uniprot ID | Q5XIC6 |
|---|---|
| Protein Name | 26S proteasome non-ATPase regulatory subunit 12 |
| Gene Name | Psmd12 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 301 | KKLEEIPKYKDLLKL |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair
Protein Sequence
10
MADGGSERAD
20
GRIVKMEVDY
30
SATVDQRLPE
40
CEKLAKEGRL
50
QEVIETLLSL
60
EKQTRTASDM
70
VSTSRILVAV
80
VKMCYEAKEW
90
DLLNENIMLL
100
SKRRSQLKQA
110
VAKMVQQCCT
120
YVEEITDLPV
130
KLRLIDTLRM
140
VTEGKIYVEI
150
ERARLTKTLA
160
TIKEQNGDVK
170
EAASILQELQ
180
VETYGSMEKK
190
ERVEFILEQM
200
RLCLAVKDYI
210
RTQIISKKIN
220
TKFFQEENTE
230
KLKLKYYNLM
240
IQLDQHEGSY
250
LSICKHYRAI
260
YDTPCIQAES
270
DKWQQALKSV
280
VLYVILAPFD
290
NEQSDLVHRI
300
SSDKKLEEIP
310
KYKDLLKLFT
320
TMELMRWSTL
330
VEDYGVELRK
340
GSSETPATDV
350
FSSTEEGEKR
360
WKDLKNRVVE
370
HNIRIMAKYY
380
TRITMKRMAQ
390
LLDLSVDESE
400
AFLSNLVVNK
410
TIFAKVDRLA
420
GVINFQRPKD
430
PNNLLNDWSQ
440
KLNSLMSLVN
450
KTTHLIAKEE
MIHNLQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0008541 | proteasome regulatory particle, lid subcomplex |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Biological Process | GO:0010498 | proteasomal protein catabolic process |
| Biological Process | GO:2000311 | regulation of AMPA receptor activity |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.