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Overview

Uniprot IDQ5XID1
Protein NameAnamorsin
Gene NameCiapin1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
175 VGSSSQLKLLHKKSS
180 QLKLLHKKSSSVKPV
185 HKKSSSVKPVVDPAT
245 GKKRKACKNCTCGLA

Function

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells

Protein Sequence

10 MAEFGISPGQ 20 LVAVFCDKSS 30 SEEALKKLVG 40 RVQGLTGSEG 50 QVFVENITQL 60 LQSAHKESSF 70 DVILSGIVPG 80 STSLHSPEAL 90 ADMARILRPG 100 GCLFLKEPVE 110 TTGVNNDKIK 120 TASKLCSALT 130 LSGLVEIKEL 140 QREALSPEEA 150 QSMQEHLGYH 160 SDSLLSVHVT 170 GKKPNFEVGS 180 SSQLKLLHKK 190 SSSVKPVVDP 200 ATAKLWTLSA 210 NDMEDDSMDL 220 IDSDELLDPE 230 DLKKPDPASL 240 KAPSCGEGKK 250 RKACKNCTCG 260 LAEELEKEQS 270 KAQSSQPKSA 280 CGNCYLGDAF 290 RCANCPYLGM 300 PAFKPGEQVL LSSSNLQDA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0097361 cytosolic [4Fe-4S] assembly targeting complex
Cellular Component GO:0005758 mitochondrial intermembrane space
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0051537 2 iron, 2 sulfur cluster binding
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0005506 iron ion binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0030097 hemopoiesis
Biological Process GO:0016226 iron-sulfur cluster assembly
Biological Process GO:0043066 negative regulation of apoptotic process

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.