Search Results
Overview
| Uniprot ID | Q5XIE6 |
|---|---|
| Protein Name | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial |
| Gene Name | Hibch |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 296 | PFAMEQIKVINKMSP |
| 352 | VRAVLIDKDQTPKWK |
| 91 | IIKGAGGKAFCAGGD |
Function
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity)
Protein Sequence
10
MGQQFVWRLQ
20
SRFSSIRRAS
30
VILQHLRMSK
40
HTETAEVLLE
50
RRGCAGVITL
60
NRPKLLNALS
70
LNMIRQIYPQ
80
LKKWERDPDT
90
FLIIIKGAGG
100
KAFCAGGDIK
110
ALSEAKKAGQ
120
TLSQDLFREE
130
YILNNAIASC
140
QKPYVALIDG
150
ITMGGGVGLS
160
VHGQFRVATE
170
RSLFAMPETG
180
IGLFPDVGGG
190
YFLPRLQGKL
200
GYFLALTGFR
210
LKGRDVHRAG
220
IATHFVDSEK
230
LHVLEEELLA
240
LKSPSAEDVA
250
GVLESYHAKS
260
KMGQDKSIIF
270
EEHMDKINSC
280
FSANTVEQIL
290
ENLRQDGSPF
300
AMEQIKVINK
310
MSPTSLKITL
320
RQLMEGSTKT
330
LQEVLTMEYR
340
LTQACMEGHD
350
FHEGVRAVLI
360
DKDQTPKWKP
370
ADLKDVTDED
380
LNSYFKSLGS
RDLKF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity |
| Biological Process | GO:0006574 | L-valine catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.