Overview
| Uniprot ID | Q5XIF4 |
|---|
| Protein Name | Small ubiquitin-related modifier 3 |
|---|
| Gene Name | Sumo3 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 11 |
EKPKEGVKTENDHIN |
| 7 |
*MSEEKPKEGVKTEN |
Function
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity)
Protein Sequence
10
MSEEKPKEGV
20
KTENDHINLK
30
VAGQDGSVVQ
40
FKIKRHTPLS
50
KLMKAYCERQ
60
GLSMRQIRFR
70
FDGQPINETD
80
TPAQLEMEDE
90
DTIDVFQQQT
100
GGTASRASVP
110
TPSHFPDICY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0016605 |
PML body |
| Molecular Function |
GO:0031386 |
protein tag activity |
| Molecular Function |
GO:0044389 |
ubiquitin-like protein ligase binding |
| Biological Process |
GO:0016925 |
protein sumoylation |
| Biological Process |
GO:1900180 |
regulation of protein localization to nucleus |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.