Search Results
Overview
| Uniprot ID | Q5XIJ3 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NAD] subunit, mitochondrial |
| Gene Name | Idh3g |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 159 | PGVVTRHKDIDILIV |
| 215 | AQESGRKKVTAVHKA |
| 315 | TATRNTGKSIANKNI |
Function
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Protein Sequence
10
MALKVAIAAG
20
SAAKAIFKPA
30
LLCRPWEVLA
40
AHEAPRRSIS
50
SQQTIPPSAK
60
YGGRHTVTMI
70
PGDGIGPELM
80
LHVKSVFRHA
90
CVPVDFEEVH
100
VSSNADEEDI
110
RNAIMAIRRN
120
RVALKGNIET
130
NHNLPPSHKS
140
RNNILRTSLD
150
LYANVIHCKS
160
LPGVVTRHKD
170
IDILIVRENT
180
EGEYSSLEHE
190
SVAGVVESLK
200
IITKAKSLRI
210
AEYAFKLAQE
220
SGRKKVTAVH
230
KANIMKLGDG
240
LFLQCCREVA
250
ARYPQITFDS
260
MIVDNTTMQL
270
VSRPQQFDVM
280
VMPNLYGNIV
290
NNVCAGLVGG
300
PGLVAGANYG
310
HVYAVFETAT
320
RNTGKSIANK
330
NIANPTATLL
340
ASCMMLDHLK
350
LHSYATSIRK
360
AVLASMDNEN
370
MHTPDIGGQG
380
TTSQAIQDII
390
RHIRIINGRA
VEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045242 | isocitrate dehydrogenase complex (NAD+) |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.