Overview
| Uniprot ID | Q5XIJ4 |
|---|
| Protein Name | Mitochondrial inner membrane scaffold 1 |
|---|
| Gene Name | Mims1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 110 |
QETPSEKKEEPDPLQ |
| 247 |
TKELISEKMEETKDR |
Function
Mitochondrial inner membrane protein essential for mitochondrial homeostasis, structural integrity, and cellular metabolism. Regulates mitochondrial translation by modulating protein synthesis of mitochondrial DNA-encoded genes. Plays a critical role in skeletal muscle mass and strength by regulating mitochondrial density, function, and protein synthesis. In brown adipose tissue, regulates mitochondrial cristae remodeling in response to cold stress by interacting with mitochondrial protease YME1L1 and enhancing its proteolytic activity, promoting OMA1 degradation and regulating OPA1 processing. Required for cardiac mitochondrial homeostasis and normal cardiomyocyte contractile function. In skeletal muscle, positively regulates myoblast differentiation by enhancing expression of myogenic factors
Protein Sequence
10
MQWNVPRTMS
20
RLALRTFLEA
30
QKARLFDHHR
40
STKGLLLVHR
50
GEYRVAWTPH
60
LRKQWLHLSA
70
VQCLAKQRNL
80
LDAQPPQRGA
90
LPQGRWEQDI
100
LSKRVLSSSS
110
TSQETPSEKK
120
EEPDPLQDKS
130
ISLYQRFKKT
140
FRQYGKVLIP
150
VHLITSGIWF
160
GTFYYASIKG
170
VNVIPFLEFL
180
GLPDSVVDIL
190
KNSQSGNALT
200
AYAMFKIATP
210
ARYTVTLGGT
220
SFTVKYLRSH
230
GYMSTPPPVK
240
EYLQGRMEET
250
KELISEKMEE
260
TKDRLTEKLQ
270
ETKEKVSFKK
KVE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.