Search Results

Overview

Uniprot IDQ5XIN6
Protein NameMitochondrial proton/calcium exchanger protein
Gene NameLetm1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
161 QKILDELKHYYHGFR
450 VAKEAQVKAAEVEGE
462 EGEQVDNKAKLEATL
491 KRAAETAKDIQPEVA
586 SEDLQEIKKELSKTG
591 EIKKELSKTGDEKYI
596 LSKTGDEKYIEESTA
605 IEESTASKRLSKRVQ
732 KAKEKAEKEAAEVKN

Function

Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). Essential for early embryonic development (By similarity)

Protein Sequence

10 MASILLRSCR 20 GRGPARLASP 30 RAASPRGSLR 40 DRACLSCTRT 50 VGLTSHESVL 60 SRCCTPANPV 70 YLYFKSEPLS 80 CWTQRPECQG 90 TVARAAWTPA 100 SARLVVTGPQ 110 YLPVRGWHSS 120 SPLGEDSMIE 130 KSLKSLKDKN 140 KKLEEGGPVY 150 SPPAQVVVKK 160 SLGQKILDEL 170 KHYYHGFRLL 180 WIDTKIAARM 190 LWRILNGHTL 200 TRRERRQFLR 210 ICADLFRLVP 220 FLVFVVVPFM 230 EFLLPVVVKL 240 FPNMLPSTFE 250 TQSIKEERLK 260 KELRVKLELA 270 KFLQDTIEEM 280 ALKNKAAKGN 290 ATKDFSAFFQ 300 KIRETGERPS 310 NEEIMRFSKL 320 FEDELTLDNL 330 TRPQLVALCK 340 LLELQSIGTN 350 NFLRFQLTMR 360 LRSIKADDKL 370 ISEEGVDSLT 380 VKELQAACRA 390 RGMRALGVTE 400 DRLKGQLKQW 410 LDLHLYHEIP 420 TSLLILSRAM 430 YLPDTLSPAD 440 QLKSTLQTLP 450 EIVAKEAQVK 460 AAEVEGEQVD 470 NKAKLEATLQ 480 EEAAIQQEHL 490 EELKRAAETA 500 KDIQPEVAEA 510 TVPGRPGAEL 520 QPKMVDVIPP 530 SEILKDTAPV 540 LEGLKGEEIT 550 KEEIDILSDA 560 CSKLKEQKKS 570 LTKEKEELEL 580 LKEDVQDYSE 590 DLQEIKKELS 600 KTGDEKYIEE 610 STASKRLSKR 620 VQQMIGQIDG 630 LITQLETTQQ 640 NGKLDPAAAS 650 SPTGESVISV 660 DELISAMKQI 670 KHIPEHKLIS 680 LTSALDENKD 690 GNINIDDLVK 700 VIDLVNKEDV 710 QISTTQVAEI 720 VATLEKEEKV 730 EEKEKAKEKA EKEAAEVKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0015369 calcium:proton antiporter activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0043022 ribosome binding
Biological Process GO:0099093 calcium export from the mitochondrion
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0042407 cristae formation
Biological Process GO:0007007 inner mitochondrial membrane organization
Biological Process GO:0051560 mitochondrial calcium ion homeostasis
Biological Process GO:0006851 mitochondrial calcium ion transmembrane transport
Biological Process GO:0140141 mitochondrial potassium ion transmembrane transport
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0051562 negative regulation of mitochondrial calcium ion concentration
Biological Process GO:0034214 protein hexamerization
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:1900069 regulation of cellular hyperosmotic salinity response

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.