Overview
| Uniprot ID | Q5XIP9 |
|---|
| Protein Name | Transmembrane protein 43 |
|---|
| Gene Name | Tmem43 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 159 |
RSEIVSSKNFDREIG |
Function
May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (By similarity). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing (By similarity)
Protein Sequence
10
MAANYSSTGS
20
RKEHVKVTSD
30
PQPGFLERLS
40
ETSGGMFVGL
50
VTFLLSFYLI
60
FTNEGRALKT
70
ANLLAEGLSL
80
VVSPDSIHSV
90
APENEGRLVH
100
IIGALRTSKL
110
LSDPNYGVHL
120
PAVKLRRHVE
130
MYQWVETEES
140
NEYTEDGQVK
150
KETKYSYNTE
160
WRSEIVSSKN
170
FDREIGHKNP
180
SAMAVESFTA
190
TAPFVQIGRF
200
FLSAGLIDKI
210
DNFKPLSLAK
220
LEDPHVDIIR
230
RGDFFYHSEN
240
PKYPEVGDVR
250
VSFSYAGLSS
260
DDPDLGPAHV
270
VTVIARQRGD
280
QLIPYSTKSG
290
DTLLLLHHGD
300
FSAEEVFRRE
310
QKSNSMKTWG
320
LRAAGWMAMF
330
MGLNLMTRIL
340
YTLVDWFPVF
350
RDLVNIGLKA
360
FAFCVATSLT
370
LLTVAAGWLF
380
YRPLWAALLG
390
CLALVPIIIA
400
RTRVPTKKLE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0005637 |
nuclear inner membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0022843 |
voltage-gated monoatomic cation channel activity |
| Molecular Function |
GO:0005249 |
voltage-gated potassium channel activity |
| Molecular Function |
GO:0005248 |
voltage-gated sodium channel activity |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0006629 |
lipid metabolic process |
| Biological Process |
GO:0007613 |
memory |
| Biological Process |
GO:0030001 |
metal ion transport |
| Biological Process |
GO:0071763 |
nuclear membrane organization |
| Biological Process |
GO:0010650 |
positive regulation of cell communication by electrical coupling |
| Biological Process |
GO:0006813 |
potassium ion transport |
| Biological Process |
GO:0006814 |
sodium ion transport |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.