Search Results
Overview
| Uniprot ID | Q5XIU9 |
|---|---|
| Protein Name | Membrane-associated progesterone receptor component 2 |
| Gene Name | Pgrmc2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 187 | WEMQFKEKYDYVGRL |
Function
Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus. Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1
Protein Sequence
10
MAAGDGDVKL
20
STLGSGGERG
30
GDGSPGGAGA
40
TAARSSWVAA
50
LLATGGEMLL
60
NVALVALVLL
70
GAYRLWVRWG
80
RRGLCSGPGA
90
GEESPAATLP
100
RMKKRDFSLE
110
QLRQYDGART
120
PRILLAVNGK
130
VFDVTKGSKF
140
YGPAGPYGIF
150
AGRDASRGLA
160
TFCLDKDALR
170
DEYDDLSDLN
180
AVQMESVREW
190
EMQFKEKYDY
200
VGRLLKPGEE
210
PSEYTDEEDT
KDHSKQD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0015232 | heme transmembrane transporter activity |
| Molecular Function | GO:0005496 | steroid binding |
| Biological Process | GO:0060612 | adipose tissue development |
| Biological Process | GO:0015886 | heme transport |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.