Search Results
Overview
| Uniprot ID | Q5XIW8 |
|---|---|
| Protein Name | U4/U6.U5 tri-snRNP-associated protein 1 |
| Gene Name | Sart1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 183 | EKRLLNQKLGKIKTL |
| 663 | LLETTVQKVARVKAP |
| 672 | ARVKAPNKSLPSAVY |
Function
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA
Protein Sequence
10
MGSSKKHRGE
20
KEAAGTTAAA
30
GTGGTTEQPP
40
RHREHKKHKH
50
RSSGGGSSGG
60
ERRKRSRERG
70
AERGSGRRGA
80
EAEARSGAHG
90
RERSQAEPSE
100
RRVKREKRDE
110
GYEAAASSKA
120
SSGDASSLSI
130
EETNKLRAKL
140
GLKPLEVNAV
150
KKEAGTKEEP
160
VAADVINPMA
170
LRQREELREK
180
LAAAKEKRLL
190
NQKLGKIKTL
200
GEDDPWLDDT
210
AAWIERSRQL
220
QKEKDLAEKR
230
AKLLEEMDQE
240
FGVSTLVEEE
250
FEQRRQDLYS
260
ARDLQGLTVE
270
HAIDSFREGE
280
TVVLTLKDKG
290
VLQEGEDVLV
300
NVNMVDKERA
310
DKNVELRKKK
320
PDYLPYAEDE
330
SVDDLAQQKP
340
RSILAKYDEE
350
LEGERPHSFR
360
LEQGGMADGL
370
RERELEEIRT
380
KLRLQAQSLN
390
TVGPRLASEY
400
LSPEEMVTFK
410
KTKRRVKKIR
420
KKEKEVIMRA
430
DDLLPLGEDQ
440
TQDGDFGSRL
450
RGRGRRRVPE
460
VEEEALEDEE
470
KDPVAQPPPS
480
DDTRVENMDI
490
SDEEDGGALP
500
SGPPELEEDE
510
AELELQKQLE
520
KGRRLRQLQQ
530
LQQLRDSGEK
540
VLEIVKKLES
550
RQRGWEEEED
560
PERKGTIVFN
570
ATSEFCRTLG
580
EIPTYGLAGN
590
REEQEELMDF
600
ERDEERSANG
610
GSESDGEENI
620
GWSTVNLDEE
630
KQHQDFSASS
640
TTILDEEPIV
650
NRGLAAALLL
660
CQNKGLLETT
670
VQKVARVKAP
680
NKSLPSAVYC
690
IEDKMAIDDK
700
YSRREEYRGF
710
TQDFKEKDGY
720
KPDVKIEYVD
730
ETGRKLTPKE
740
AFRQLSHRFH
750
GKGSGKMKTE
760
RRMKKLDEEA
770
LLKKMSSSDT
780
PLGTVALLQE
790
KQKAQKTPYI
800
VLSGSGKSMN
ANTITK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015030 | Cajal body |
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0071011 | precatalytic spliceosome |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071016 | U12-type precatalytic spliceosome |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Biological Process | GO:0000481 | maturation of 5S rRNA |
| Biological Process | GO:0045292 | mRNA cis splicing, via spliceosome |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0045585 | positive regulation of cytotoxic T cell differentiation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.