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Overview

Uniprot IDQ5XKE0
Protein NameMyosin-binding protein C, fast-type
Gene NameMybpc2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
1030 LKTGITLKPLEYKEH
1035 TLKPLEYKEHDFRTA
1073 VRGHPKPKVVWMKNK
1080 KVVWMKNKMEIHEDP
137 YRLEIKAKDVCDSCS
165 GQSLESFKRSGDGKS
24 APKEAPAKQTPEEPP
256 KSAAFTKKLDPAYQV
304 YVFENVGKKRILTIN
454 AAEQAVFKCEVSDEK
461 KCEVSDEKVTGKWYK
53 PTGIFLKKPDSVSVE
530 IKVEYVPKQEPPKIH
543 IHLDCSGKTSDNSIV
88 TIKWFKGKWQELGSK
95 KWQELGSKSGARFIF

Function

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity)

Protein Sequence

10 MPEAKPAAKK 20 ASKGKDAPKE 30 APAKQTPEEP 40 PKEAPPEDQS 50 PTAEEPTGIF 60 LKKPDSVSVE 70 TGKDAVILAK 80 VNGKELPGKP 90 TIKWFKGKWQ 100 ELGSKSGARF 110 IFKESHDSTS 120 NVYTVELHIG 130 KVVLGDRGDY 140 RLEIKAKDVC 150 DSCSFNVDVE 160 APRQDSSGQS 170 LESFKRSGDG 180 KSEDAGELDF 190 SGLLKKREVV 200 EEEKKKKKDD 210 DDLGIPPEIW 220 ELLKGAKKSE 230 YEKIAFQYGI 240 TDLRGMLKRL 250 KKAKVEVKKS 260 AAFTKKLDPA 270 YQVDRGNKIK 280 LVVEISDPDL 290 PLKWFKNGQE 300 IKPSSKYVFE 310 NVGKKRILTI 320 NKCTLADDAA 330 YEVAVQDEKC 340 FTELFVKEPP 350 VLIVTPLEDQ 360 QVFVGDRVEM 370 SVEVSEEGAQ 380 VMWMKDGVEM 390 TREDSYKARY 400 RFKKDGKRHI 410 LIYSDVAQED 420 GGRYQVITNG 430 GQCEAELIVE 440 EKQLEVLQDI 450 ADLTVKAAEQ 460 AVFKCEVSDE 470 KVTGKWYKNG 480 VEVRPSKRIT 490 ISHVGRFHKL 500 VIDDVRPEDE 510 GDYTFVPDGY 520 ALSLSAKLNF 530 LEIKVEYVPK 540 QEPPKIHLDC 550 SGKTSDNSIV 560 VVAGNKLRLD 570 VAITGEPPPT 580 ATWLRGDEVF 590 TATEGRTHIE 600 QRPDCSSFVI 610 ESAERSDEGR 620 YTIKVTNPVG 630 EDVASIFLRV 640 VDVPDPPEAV 650 RVTSVGEDWA 660 ILVWEPPKYD 670 GGQPVTGYLM 680 ERKKKGSQRW 690 MKINFEVFTD 700 TTYESTKMIE 710 GVLYEMRVFA 720 VNAIGVSQPS 730 MNTKPFMPIA 740 PTSAPQHLTV 750 EDVTDTTTTL 760 KWRPPDRIGA 770 GGIDGYLVEY 780 CLEGSEEWVP 790 ANKEPVERCG 800 FTVKDLPTGA 810 RILFRVVGVN 820 IAGRSEPATL 830 LQPVTIREIV 840 EQPKIRLPRH 850 LRQTYIRKVG 860 EALNLVIPFQ 870 GKPRPQVVWT 880 KGGAPLDTSR 890 VNVRTSDFDT 900 VFFVRQAARS 910 DSGEYELSVQ 920 IENMKDTATI 930 RIRVVEKAGP 940 AENVMVKEVW 950 GTNALVEWQP 960 PKDDGNSEIT 970 GYFVQKADKK 980 TMEWFNVYEH 990 NRHTSCTVSD 1000 LIVGNEYYFR 1010 IFSENICGLS 1020 DSPGVSKNTA 1030 RILKTGITLK 1040 PLEYKEHDFR 1050 TAPKFLTPLM 1060 DRVVVAGYTA 1070 ALNCAVRGHP 1080 KPKVVWMKNK 1090 MEIHEDPKFL 1100 ITNYQGILTL 1110 NIRRPSPFDA 1120 GTYSCRAFNE 1130 LGEALAECKL DVRVPQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0031430 M band
Cellular Component GO:0032982 myosin filament
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0008307 structural constituent of muscle
Biological Process GO:0007155 cell adhesion
Biological Process GO:0006936 muscle contraction
Biological Process GO:0045214 sarcomere organization

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.