Overview
| Uniprot ID | Q5XXA6 |
|---|
| Protein Name | Anoctamin-1 |
|---|
| Gene Name | ANO1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 180 |
KLKMPTKKMYHINET |
Function
Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (PubMed:28963502). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825). However, was shown in another study not to be required for MUC5AC expression (PubMed:31732694). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G protein-coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity)
Protein Sequence
10
MRVNEKYSTL
20
PAEDRSVHII
30
NICAIEDIGY
40
LPSEGTLLNS
50
LSVDPDAECK
60
YGLYFRDGRR
70
KVDYILVYHH
80
KRPSGNRTLV
90
RRVQHSDTPS
100
GARSVKQDHP
110
LPGKGASLDA
120
GSGEPPMDYH
130
EDDKRFRREE
140
YEGNLLEAGL
150
ELERDEDTKI
160
HGVGFVKIHA
170
PWNVLCREAE
180
FLKLKMPTKK
190
MYHINETRGL
200
LKKINSVLQK
210
ITDPIQPKVA
220
EHRPQTMKRL
230
SYPFSREKQH
240
LFDLSDKDSF
250
FDSKTRSTIV
260
YEILKRTTCT
270
KAKYSMGITS
280
LLANGVYAAA
290
YPLHDGDYNG
300
ENVEFNDRKL
310
LYEEWARYGV
320
FYKYQPIDLV
330
RKYFGEKIGL
340
YFAWLGVYTQ
350
MLIPASIVGI
360
IVFLYGCATM
370
DENIPSMEMC
380
DQRHNITMCP
390
LCDKTCSYWK
400
MSSACATARA
410
SHLFDNPATV
420
FFSVFMALWA
430
ATFMEHWKRK
440
QMRLNYRWDL
450
TGFEEEEEAV
460
KDHPRAEYEA
470
RVLEKSLKKE
480
SRNKEKRRHI
490
PEESTNKWKQ
500
RVKTAMAGVK
510
LTDKVKLTWR
520
DRFPAYLTNL
530
VSIIFMIAVT
540
FAIVLGVIIY
550
RISMAAALAM
560
NSSPSVRSNI
570
RVTVTATAVI
580
INLVVIILLD
590
EVYGCIARWL
600
TKIEVPKTEK
610
SFEERLIFKA
620
FLLKFVNSYT
630
PIFYVAFFKG
640
RFVGRPGDYV
650
YIFRSFRMEE
660
CAPGGCLMEL
670
CIQLSIIMLG
680
KQLIQNNLFE
690
IGIPKMKKLI
700
RYLKLKQQSP
710
PDHEECVKRK
720
QRYEVDYNLE
730
PFAGLTPEYM
740
EMIIQFGFVT
750
LFVASFPLAP
760
LFALLNNIIE
770
IRLDAKKFVT
780
ELRRPVAVRA
790
KDIGIWYNIL
800
RGIGKLAVII
810
NAFVISFTSD
820
FIPRLVYLYM
830
YSKNGTMHGF
840
VNHTLSSFNV
850
SDFQNGTAPN
860
DPLDLGYEVQ
870
ICRYKDYREP
880
PWSENKYDIS
890
KDFWAVLAAR
900
LAFVIVFQNL
910
VMFMSDFVDW
920
VIPDIPKDIS
930
QQIHKEKVLM
940
VELFMREEQD
950
KQQLLETWME
960
KERQKDEPPC
970
NHHNTKACPD
980
SLGSPAPSHA
YHGGVL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0034707 |
chloride channel complex |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098793 |
presynapse |
| Molecular Function |
GO:0005227 |
calcium-activated cation channel activity |
| Molecular Function |
GO:0005254 |
chloride channel activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005229 |
intracellularly calcium-gated chloride channel activity |
| Molecular Function |
GO:0015111 |
iodide transmembrane transporter activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Molecular Function |
GO:0005247 |
voltage-gated chloride channel activity |
| Biological Process |
GO:0034605 |
cellular response to heat |
| Biological Process |
GO:1901653 |
cellular response to peptide |
| Biological Process |
GO:1902476 |
chloride transmembrane transport |
| Biological Process |
GO:0006821 |
chloride transport |
| Biological Process |
GO:0050965 |
detection of temperature stimulus involved in sensory perception of pain |
| Biological Process |
GO:0106091 |
glial cell projection elongation |
| Biological Process |
GO:0015705 |
iodide transport |
| Biological Process |
GO:0034220 |
monoatomic ion transmembrane transport |
| Biological Process |
GO:0070254 |
mucus secretion |
| Biological Process |
GO:0007200 |
phospholipase C-activating G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0072657 |
protein localization to membrane |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.