Search Results

Overview

Uniprot IDQ60668
Protein NameHeterogeneous nuclear ribonucleoprotein D0
Gene NameHnrnpd
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
243 VKKIMEKKYHNVGLS

Function

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation

Protein Sequence

10 MSEEQFGGDG 20 AAAAATAAVG 30 GSAGEQEGAM 40 VAAAAQGPAA 50 AAGSGSGGGG 60 SAAGGTEGGS 70 AEAEGAKIDA 80 SKNEEDEGHS 90 NSSPRHTEAA 100 AAQREEWKMF 110 IGGLSWDTTK 120 KDLKDYFSKF 130 GEVVDCTLKL 140 DPITGRSRGF 150 GFVLFKESES 160 VDKVMDQKEH 170 KLNGKVIDPK 180 RAKAMKTKEP 190 VKKIFVGGLS 200 PDTPEEKIRE 210 YFGGFGEVES 220 IELPMDNKTN 230 KRRGFCFITF 240 KEEEPVKKIM 250 EKKYHNVGLS 260 KCEIKVAMSK 270 EQYQQQQQWG 280 SRGGFAGRAR 290 GRGGGPSQNW 300 NQGYSNYWNQ 310 GYGNYGYNSQ 320 GYGGYGGYDY 330 TGYNNYYGYG 340 DYSNQQSGYG 350 KVSRRGGHQN SYKPY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0106002 mCRD-mediated mRNA stability complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0045202 synapse
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0003680 minor groove of adenine-thymine-rich DNA binding
Molecular Function GO:0035925 mRNA 3'-UTR AU-rich region binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0042162 telomeric DNA binding
Biological Process GO:0061158 3'-UTR-mediated mRNA destabilization
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0071392 cellular response to estradiol stimulus
Biological Process GO:0071732 cellular response to nitric oxide
Biological Process GO:1904586 cellular response to putrescine
Biological Process GO:0021549 cerebellum development
Biological Process GO:0097167 circadian regulation of translation
Biological Process GO:0070934 CRD-mediated mRNA stabilization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:1990828 hepatocyte dedifferentiation
Biological Process GO:0001889 liver development
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Process GO:2000767 positive regulation of cytoplasmic translation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1904355 positive regulation of telomere capping
Biological Process GO:0032212 positive regulation of telomere maintenance via telomerase
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0043488 regulation of mRNA stability
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0051602 response to electrical stimulus
Biological Process GO:1901355 response to rapamycin
Biological Process GO:1904383 response to sodium phosphate

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.