Search Results
Overview
| Uniprot ID | Q60866 |
|---|---|
| Protein Name | N-acetyltaurine hydrolase |
| Gene Name | Pter |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 90 | ELLYFKAKGGGALVE |
Function
N-acetyltaurine hydrolase that regulates feeding by catalyzing the hydrolysis of N-acetyltaurine into taurine and acetate (PubMed:39112712). N-acetyltaurine has anorexigenic and anti-obesity effects that are dependent on GFRAL receptor and GDF15 (PubMed:39112712). PTER also acts on other N-acetyl amino acids (Met, Ile, Leu, Val) and N-propionyltaurine, but at lower rates (PubMed:39112712)
Protein Sequence
10
MSSLSGKVQT
20
VLGLVEPSQL
30
GRTLTHEHLT
40
MTFDSFYCPP
50
PPCHEVTSKE
60
PIMMKNLFWI
70
QKNPYSHREN
80
LQLNQEVGAI
90
REELLYFKAK
100
GGGALVENTT
110
TGLSRDVHTL
120
KWLAEQTGVH
130
IIAGAGFYVD
140
ATHSAATRAM
150
SVEQLTDVLI
160
NEILHGADGT
170
SIKCGVIGEI
180
GCSWPLTDSE
190
RKILEATAHA
200
QAQLGCPVII
210
HPGRNPGAPF
220
QIIRILQEAG
230
ADISKTVMSH
240
LDRTIFDKKE
250
LLEFAQLGCY
260
LEYDLFGTEL
270
LNYQLSPDID
280
MPDDNKRIRR
290
VHFLVDEGYE
300
DRILMAHDIH
310
TKHRLMKYGG
320
HGYSHILTNI
330
VPKMLLRGLT
340
ERVLDKILIE
NPKQWLTFK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0141215 | N-acetyltaurine hydrolase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0032098 | regulation of appetite |
| Biological Process | GO:0019530 | taurine metabolic process |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.