Search Results

Overview

Uniprot IDQ60931
Protein NameNon-selective voltage-gated ion channel VDAC3
Gene NameVdac3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
12 PTYCDLGKAAKDVFN
15 CDLGKAAKDVFNKGY
163 SFDTAKSKLSQNNFA
63 GNLETKYKVCNYGLT

Function

Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (By similarity). Involved in male fertility and sperm mitochondrial sheath formation (PubMed:35228556)

Protein Sequence

10 MCNTPTYCDL 20 GKAAKDVFNK 30 GYGFGMVKID 40 LKTKSCSGVE 50 FSTSGHAYTD 60 TGKASGNLET 70 KYKVCNYGLT 80 FTQKWNTDNT 90 LGTEISWENK 100 LAEGLKLTLD 110 TIFVPNTGKK 120 SGKLKASYRR 130 DCFSLGSNVD 140 IDFSGPTIYG 150 WAVLAFEGWL 160 AGYQMSFDTA 170 KSKLSQNNFA 180 LGYKAADFQL 190 HTHVNDGTEF 200 GGSIYQKVNE 210 RIETSINLAW 220 TAGSNNTRFG 230 IAAKYKLDCR 240 TSLSAKVNNA 250 SLIGLGYTQT 260 LRPGVKLTLS 270 ALIDGKNFNA 280 GGHKVGLGFE LEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0046930 pore complex
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0015288 porin activity
Molecular Function GO:0008308 voltage-gated monoatomic anion channel activity
Molecular Function GO:0005244 voltage-gated monoatomic ion channel activity
Biological Process GO:0001662 behavioral fear response
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0007612 learning
Biological Process GO:0007270 neuron-neuron synaptic transmission
Biological Process GO:0120317 sperm mitochondrial sheath assembly
Biological Process GO:0007283 spermatogenesis

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.