Overview
| Uniprot ID | Q60973 |
|---|
| Protein Name | Histone-binding protein RBBP7 |
|---|
| Gene Name | Rbbp7 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 316 |
LHTFESHKDEIFQVH |
Function
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity)
Protein Sequence
10
MASKEMFEDT
20
VEERVINEEY
30
KIWKKNTPFL
40
YDLVMTHALQ
50
WPSLTVQWLP
60
EVTKPEGKDY
70
ALHWLVLGTH
80
TSDEQNHLVV
90
ARVHIPNDDA
100
QFDASHCDSD
110
KGEFGGFGSV
120
TGKIECEIKI
130
NHEGEVNRAR
140
YMPQNPHIIA
150
TKTPSSDVLV
160
FDYTKHPAKP
170
DPSGECNPDL
180
RLRGHQKEGY
190
GLSWNSNLSG
200
HLLSASDDHT
210
VCLWDINAGP
220
KEGKIVDAKA
230
IFTGHSAVVE
240
DVAWHLLHES
250
LFGSVADDQK
260
LMIWDTRSNT
270
TSKPSHLVDA
280
HTAEVNCLSF
290
NPYSEFILAT
300
GSADKTVALW
310
DLRNLKLKLH
320
TFESHKDEIF
330
QVHWSPHNET
340
ILASSGTDRR
350
LNVWDLSKIG
360
EEQSAEDAED
370
GPPELLFIHG
380
GHTAKISDFS
390
WNPNEPWVIC
400
SVSEDNIMQI
410
WQMAENIYND
420
EESDVTASEL
EGQGS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:1904949 |
ATPase complex |
| Biological Process |
GO:0042659 |
regulation of cell fate specification |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:2000736 |
regulation of stem cell differentiation |
| Biological Process |
GO:0048545 |
response to steroid hormone |
| Cellular Component |
GO:0000781 |
chromosome, telomeric region |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0035098 |
ESC/E(Z) complex |
| Cellular Component |
GO:0000118 |
histone deacetylase complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0016581 |
NuRD complex |
| Cellular Component |
GO:0016589 |
NURF complex |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0007420 |
brain development |
| Biological Process |
GO:0070370 |
cellular heat acclimation |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0006260 |
DNA replication |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0030308 |
negative regulation of cell growth |
| Biological Process |
GO:0030336 |
negative regulation of cell migration |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:1902455 |
negative regulation of stem cell population maintenance |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:1902459 |
positive regulation of stem cell population maintenance |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.