Search Results
Overview
| Uniprot ID | Q61598 |
|---|---|
| Protein Name | Rab GDP dissociation inhibitor beta |
| Gene Name | Gdi2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 164 | TFEGVDPKKTSMRDV |
Function
GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A
Protein Sequence
10
MNEEYDVIVL
20
GTGLTECILS
30
GIMSVNGKKV
40
LHMDQNPYYG
50
GESASITPLE
60
DLYKRFKLPG
70
QPPASMGRGR
80
DWNVDLIPKF
90
LMANGQLVKM
100
LLFTEVTRYM
110
DFKVIEGSFV
120
YKGGKIYKVP
130
STEAEALASS
140
LMGLFEKRRF
150
RKFLVYVANF
160
DEKDPRTFEG
170
VDPKKTSMRD
180
VYKKFDLGQD
190
VIDFTGHSLA
200
LYRTDDYLDQ
210
PCCETINRIK
220
LYSESLARYG
230
KSPYLYPLYG
240
LGELPQGFAR
250
LSAIYGGTYM
260
LNKPIEEIIV
270
QNGKVVGVKS
280
EGEIARCKQL
290
ICDPSYVKDR
300
VEKVGQVIRV
310
ICILSHPIKN
320
TNDANSCQII
330
IPQNQVNRKS
340
DIYVCMISFA
350
HNVAAQGKYI
360
AIVSTTVETK
370
EPEKEIRPAL
380
ELLEPIEQKF
390
VSISDLFVPK
400
DLGTDSQIFI
410
SRAYDATTHF
420
ETTCDDIKDI
430
YKRMTGSEFD
440
FEEMKRKKND
IYGED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0005093 | Rab GDP-dissociation inhibitor activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:1902018 | negative regulation of cilium assembly |
| Biological Process | GO:1903565 | negative regulation of protein localization to cilium |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.