Search Results
Overview
| Uniprot ID | Q61792 |
|---|---|
| Protein Name | LIM and SH3 domain protein 1 |
| Gene Name | Lasp1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | PELQRIKKTQDQISN |
Function
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity)
Protein Sequence
10
MNPNCARCGK
20
IVYPTEKVNC
30
LDKYWHKACF
40
HCETCKMTLN
50
MKNYKGYEKK
60
PYCNAHYPKQ
70
SFTMVADTPE
80
NLRLKQQSEL
90
QSQVRYKEEF
100
EKNKGKGFSV
110
VADTPELQRI
120
KKTQDQISNI
130
KYHEEFEKSR
140
MGPSGGEGVE
150
PERREAQDSS
160
SYRRPTEQQQ
170
PQPHHIPTSA
180
PVYQQPQQQQ
190
MTSSYGGYKE
200
PAAPVSIQRS
210
APGGGGKRYR
220
AVYDYSAADE
230
DEVSFQDGDT
240
IVNVQQIDDG
250
WMYGTVERTG
260
DTGMLPANYV
EAI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0015075 | monoatomic ion transmembrane transporter activity |
| Biological Process | GO:0006811 | monoatomic ion transport |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.