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Overview

Uniprot IDQ61838
Protein NamePregnancy zone protein
Gene NamePzp
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
607 DQSVLLLKPEAKLSP

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase

Protein Sequence

10 MRRNQLPTPA 20 FLLLFLLLPR 30 DATTATAKPQ 40 YVVLVPSEVY 50 SGVPEKACVS 60 LNHVNETVML 70 SLTLEYAMQQ 80 TKLLTDQAVD 90 KDSFYCSPFT 100 ISGSPLPYTF 110 ITVEIKGPTQ 120 RFIKKKSIQI 130 IKAESPVFVQ 140 TDKPIYKPGQ 150 IVKFRVVSVD 160 ISFRPLNETF 170 PVVYIETPKR 180 NRIFQWQNIH 190 LAGGLHQLSF 200 PLSVEPALGI 210 YKVVVQKDSG 220 KKIEHSFEVK 230 EYVLPKFEVI 240 IKMQKTMAFL 250 EEELPITACG 260 VYTYGKPVPG 270 LVTLRVCRKY 280 SRYRSTCHNQ 290 NSMSICEEFS 300 QQADDKGCFR 310 QVVKTKVFQL 320 RQKGHDMKIE 330 VEAKIKEEGT 340 GIELTGIGSC 350 EIANALSKLK 360 FTKVNTNYRP 370 GLPFSGQVLL 380 VDEKGKPIPN 390 KNITSVVSPL 400 GYLSIFTTDE 410 HGLANISIDT 420 SNFTAPFLRV 430 VVTYKQNHVC 440 YDNWWLDEFH 450 TQADHSATLV 460 FSPSQSYIQL 470 ELVFGTLACG 480 QTQEIRIHYL 490 LNEDIMKNEK 500 DLTFYYLIKA 510 RGSIFNLGSH 520 VLSLEQGNMK 530 GVFSLPIQVE 540 PGMAPEAQLL 550 IYAILPNEEL 560 VADAQNFEIE 570 KCFANKVNLS 580 FPSAQSLPAS 590 DTHLKVKAAP 600 LSLCALTAVD 610 QSVLLLKPEA 620 KLSPQSIYNL 630 LPGKTVQGAF 640 FGVPVYKDHE 650 NCISGEDITH 660 NGIVYTPKHS 670 LGDNDAHSIF 680 QSVGINIFTN 690 SKIHKPRFCQ 700 EFQHYPAMGG 710 VAPQALAVAA 720 SGPGSSFRAM 730 GVPMMGLDYS 740 DEINQVVEVR 750 ETVRKYFPET 760 WIWDLVPLDV 770 SGDGELAVKV 780 PDTITEWKAS 790 AFCLSGTTGL 800 GLSSTISLQA 810 FQPFFLELTL 820 PYSVVRGEAF 830 TLKATVLNYM 840 SHCIQIRVDL 850 EISPDFLAVP 860 VGGHENSHCI 870 CGNERKTVSW 880 AVTPKSLGEV 890 NFTATAEALQ 900 SPELCGNKLT 910 EVPALVHKDT 920 VVKSVIVEPE 930 GIEKEQTYNT 940 LLCPQDTELQ 950 DNWSLELPPN 960 VVEGSARATH 970 SVLGDILGSA 980 MQNLQNLLQM 990 PYGCGEQNMV 1000 LFVPNIYVLN 1010 YLNETQQLTE 1020 AIKSKAINYL 1030 ISGYQRQLNY 1040 QHSDGSYSTF 1050 GNHGGGNTPG 1060 NTWLTAFVLK 1070 AFAQAQSHIF 1080 IEKTHITNAF 1090 NWLSMKQKEN 1100 GCFQQSGYLL 1110 NNAMKGGVDD 1120 EVTLSAYITI 1130 ALLEMPLPVT 1140 HSAVRNALFC 1150 LETAWASISQ 1160 SQESHVYTKA 1170 LLAYAFALAG 1180 NKAKRSELLE 1190 SLNKDAVKEE 1200 DSLHWQRPGD 1210 VQKVKALSFY 1220 QPRAPSAEVE 1230 MTAYVLLAYL 1240 TSESSRPTRD 1250 LSSSDLSTAS 1260 KIVKWISKQQ 1270 NSHGGFSSTQ 1280 DTVVALQALS 1290 KYGAATFTRS 1300 QKEVLVTIES 1310 SGTFSKTFHV 1320 NSGNRLLLQE 1330 VRLPDLPGNY 1340 VTKGSGSGCV 1350 YLQTSLKYNI 1360 LPVADGKAPF 1370 ALQVNTLPLN 1380 FDKAGDHRTF 1390 QIRINVSYTG 1400 ERPSSNMVIV 1410 DVKMVSGFIP 1420 MKPSVKKLQD 1430 QPNIQRTEVN 1440 TNHVLIYIEK 1450 LTNQTLGFSF 1460 AVEQDIPVKN 1470 LKPAPIKVYD 1480 YYETDEFTVE 1490 EYSAPFSDGS EQGNA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005615 extracellular space
Molecular Function GO:0004866 endopeptidase inhibitor activity
Molecular Function GO:0002020 protease binding
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.