Search Results
Overview
| Uniprot ID | Q61937 |
|---|---|
| Protein Name | Nucleophosmin |
| Gene Name | Npm1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 150 | SAPGGGNKVPQKKVK |
| 221 | KPSTPRSKGQESFKK |
| 237 | EKTPKTPKGPSSVED |
Function
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (PubMed:20513429)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:1904751 | positive regulation of protein localization to nucleolus |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001652 | granular component |
| Cellular Component | GO:0015934 | large ribosomal subunit |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0032993 | protein-DNA complex |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0015935 | small ribosomal subunit |
| Cellular Component | GO:0031616 | spindle pole centrosome |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0001046 | core promoter sequence-specific DNA binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0051059 | NF-kappaB binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0043422 | protein kinase B binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0004860 | protein kinase inhibitor activity |
| Molecular Function | GO:0043023 | ribosomal large subunit binding |
| Molecular Function | GO:0043024 | ribosomal small subunit binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0019843 | rRNA binding |
| Molecular Function | GO:0030957 | Tat protein binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0007249 | canonical NF-kappaB signal transduction |
| Biological Process | GO:0006884 | cell volume homeostasis |
| Biological Process | GO:0034644 | cellular response to UV |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0007098 | centrosome cycle |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0030225 | macrophage differentiation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0010826 | negative regulation of centrosome duplication |
| Biological Process | GO:0050680 | negative regulation of epithelial cell proliferation |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation |
| Biological Process | GO:0006913 | nucleocytoplasmic transport |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0009891 | positive regulation of biosynthetic process |
| Biological Process | GO:0043085 | positive regulation of catalytic activity |
| Biological Process | GO:1902751 | positive regulation of cell cycle G2/M phase transition |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0010825 | positive regulation of centrosome duplication |
| Biological Process | GO:2000767 | positive regulation of cytoplasmic translation |
| Biological Process | GO:0051054 | positive regulation of DNA metabolic process |
| Biological Process | GO:0045740 | positive regulation of DNA replication |
| Biological Process | GO:1900264 | positive regulation of DNA-directed DNA polymerase activity |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045860 | positive regulation of protein kinase activity |
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0010608 | post-transcriptional regulation of gene expression |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0001558 | regulation of cell growth |
| Biological Process | GO:0046599 | regulation of centriole replication |
| Biological Process | GO:0010824 | regulation of centrosome duplication |
| Biological Process | GO:0043516 | regulation of DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0060735 | regulation of eIF2 alpha phosphorylation by dsRNA |
| Biological Process | GO:1902629 | regulation of mRNA stability involved in cellular response to UV |
| Biological Process | GO:0043523 | regulation of neuron apoptotic process |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:0042273 | ribosomal large subunit biogenesis |
| Biological Process | GO:0000055 | ribosomal large subunit export from nucleus |
| Biological Process | GO:0042274 | ribosomal small subunit biogenesis |
| Biological Process | GO:0000056 | ribosomal small subunit export from nucleus |
| Biological Process | GO:0009303 | rRNA transcription |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.