Search Results

Overview

Uniprot IDQ61941
Protein NameNAD(P) transhydrogenase, mitochondrial
Gene NameNnt
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
1071 MLLGDAKKTCDALQA
1079 TCDALQAKVRESYQK
171 LNKLSERKTTVLAMD
224 GQITAAGKVPPAKIL
294 GYAKEMSKEFIEAEM
324 TALIPGKKAPVLFSK
403 LKAISPDKDNFHFEV
433 TVVMKDGKVIFPAPT
442 IFPAPTPKNIPEEAP
451 IPEEAPVKPKTVAEL
49 LWCKSPVKPGIPYKQ
70 KEIFQNEKRVALSPA

Function

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity)

Protein Sequence

10 MAHLLKTVVA 20 GCSCPFLSNL 30 GSSKVLPGKR 40 DFVRTLRTHQ 50 ALWCKSPVKP 60 GIPYKQLTVG 70 VPKEIFQNEK 80 RVALSPAGVQ 90 ALVKQGFNVV 100 VESGAGEASK 110 FPDDLYRAAG 120 AQIQGMKEVL 130 ASDLVVKVRA 140 PMVNPTLGAH 150 EADFLKPSGT 160 LISFIYPAQN 170 PDLLNKLSER 180 KTTVLAMDQV 190 PRVTIAQGYD 200 ALSSMANISG 210 YKAVVLAANH 220 FGRFFTGQIT 230 AAGKVPPAKI 240 LIVGGGVAGL 250 ASAGAAKSMG 260 AVVRGFDTRA 270 AALEQFKSLG 280 AEPLEVDLKE 290 SGEGQGGYAK 300 EMSKEFIEAE 310 MKLFAQQCKE 320 VDILISTALI 330 PGKKAPVLFS 340 KEMIESMKEG 350 SVVVDLAAEA 360 GGNFETTKPG 370 ELYVHKGITH 380 IGYTDLPSRM 390 ATQASTLYSN 400 NITKLLKAIS 410 PDKDNFHFEV 420 KDDFDFGTMS 430 HVIRGTVVMK 440 DGKVIFPAPT 450 PKNIPEEAPV 460 KPKTVAELEA 470 EKAGTVSMYT 480 KTLTTASVYS 490 AGLTGMLGLG 500 IVAPNVAFSQ 510 MVTTFGLAGI 520 IGYHTVWGVT 530 PALHSPLMSV 540 TNAISGLTAV 550 GGLALMGGHF 560 YPSTTSQSLA 570 ALATFISSVN 580 IAGGFLVTQR 590 MLDMFKRPTD 600 PPEYNYLYLL 610 PGGTFVGGYL 620 AALYGGYNIE 630 EIMYLGSGLC 640 CVGALGGLST 650 QGTARLGNAL 660 GMIGVAGGLA 670 ATLGGLKPDP 680 QLLAQMSGAM 690 AMGGTIGLTI 700 AKRIQISDLP 710 QLVAAFHSLV 720 GLAAVLTCMA 730 EYIVEYPHFA 740 MDATSNFTKI 750 VAYLGTYIGG 760 VTFSGSLVAY 770 GKLQGILKSA 780 PLLLPGRHAL 790 NAGLLAASVG 800 GIIPFMADPS 810 FTTGITCLGS 820 VSGLSTLMGV 830 TLTAAIGGAD 840 MPVVITVLNS 850 YSGWALCAEG 860 FLLNNNLLTI 870 VGALIGSSGA 880 ILSYIMCVAM 890 NRSLANVILG 900 GYGTTSTAGG 910 KPMEISGTHT 920 EINLDNAVEM 930 IREANSIVIT 940 PGYGLCAAKA 950 QYPIADLVKM 960 LTEQGKKVRF 970 GIHPVAGRMP 980 GQLNVLLAEA 990 GVPYDIVLEM 1000 DEINSDFPDT 1010 DLVLVIGAND 1020 TVNSAAQEDP 1030 NSIIAGMPVL 1040 EVWKSKQVIV 1050 MKRSLGVGYA 1060 AVDNPIFYKP 1070 NTAMLLGDAK 1080 KTCDALQAKV RESYQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0050661 NADP binding
Molecular Function GO:0016491 oxidoreductase activity
Molecular Function GO:0008750 proton-translocating NAD(P)+ transhydrogenase activity
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0098869 cellular oxidant detoxification
Biological Process GO:0032364 intracellular oxygen homeostasis
Biological Process GO:0006740 NADPH regeneration
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:1903285 positive regulation of hydrogen peroxide catabolic process
Biological Process GO:0010918 positive regulation of mitochondrial membrane potential
Biological Process GO:0072593 reactive oxygen species metabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.