Search Results

Overview

Uniprot IDQ62407
Protein NameStriated muscle-specific serine/threonine-protein kinase
Gene NameSpeg
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
1864 PWFKTEAKGAEVSTD
2088 RGGPEDGKVSGLRGP

Function

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells

Protein Sequence

10 MQKARGTRGE 20 DAGTRAPPSP 30 GVPPKRAKVG 40 AGRGVLVTGD 50 GAGAPVFLRP 60 LKNAAVCAGS 70 DVRLRVVVSG 80 TPQPSLSWFR 90 DGQLLPPPAP 100 EPSCLWLRSC 110 GAQDAGVYSC 120 SAQNERGQAS 130 CEAVLTVLEV 140 RDSETAEDDI 150 SDVPGTQRLE 160 LRDDRAFSTP 170 TGGSDTLVGT 180 SLDTPPTSVT 190 GTSEEQVSWW 200 GSGQTVLEQE 210 AGSGGGTRPL 220 PGSPRQAQTT 230 GAGPRHLGVE 240 PLVRASRANL 250 VGASWGSEDS 260 LSVASDLYGS 270 AFSLYRGRAL 280 SIHVSIPPSG 290 LHREEPDLQP 300 QPASDALRPR 310 PALPPPSKSA 320 LLPPPSPRVG 330 KRALPGPSTQ 340 PPATPTSPHR 350 RAQEPSLPED 360 ITTTEEKRGK 370 KPKSSGPSLA 380 GTVESRPQTP 390 LSEASGRLSA 400 LGRSPRLVRA 410 GSRILDKLQF 420 FEERRRSLER 430 SDSPPAPLRP 440 WVPLRKARSL 450 EQPKSEGGAA 460 WGTPEASQEE 470 LRSPRGSVAE 480 RRRLFQQKAA 490 SLDERTRQRS 500 ATSDLELRFA 510 QELGRIRRST 520 SREELVRSHE 530 SLRATLQRAP 540 SPREPGEPPL 550 FSRPSTPKTS 560 RAVSPAATQP 570 PPPSGAGKSG 580 DEPGRPRSRG 590 PVGRTEPGEG 600 PQQEIKRRDQ 610 FPLTRSRAIQ 620 ECRSPVPPYT 630 ADPPESRTKA 640 PSGRKREPPA 650 QAVRFLPWAT 660 PGVEDSVLPQ 670 TLEKNRAGPE 680 AEKRLRRGPE 690 EDGPWGPWDR 700 RGTRSQGKGR 710 RARPTSPELE 720 SSDDSYVSAG 730 EEPLEAPVFE 740 IPLQNMVVAP 750 GADVLLKCII 760 TANPPPQVSW 770 KKDGSMLHSE 780 GRLLIRAEGE 790 RHTLLLREAQ 800 AADAGSYTAT 810 ATNELGQATC 820 ASSLAVRPGG 830 STSPFSSPIT 840 SDEEYLSPPE 850 EFPEPGETWP 860 RTPTMKLSPS 870 QDHDSSDSSS 880 KAPPTFKVSL 890 MDQSVREGQD 900 VIMSIRVQGE 910 PKPVVSWLRN 920 RQPVRPDQRR 930 FAEEAEGGLC 940 RLRILAAERG 950 DAGFYTCKAV 960 NEYGARQCEA 970 RLEVRAHPES 980 RSLAVLAPLQ 990 DVDVGAGEMA 1000 LFECLVAGPA 1010 DVEVDWLCRG 1020 RLLQPALLKC 1030 KMHFDGRKCK 1040 LLLTSVHEDD 1050 SGVYTCKLST 1060 AKDELTCSAR 1070 LTVRPSLAPL 1080 FTRLLEDVEV 1090 LEGRAARLDC 1100 KISGTPPPSV 1110 TWTHFGHPVN 1120 EGDNLRLRQD 1130 GGLHSLHIAR 1140 VGSEDEGLYE 1150 VSATNTHGQA 1160 HCSAQLYVEE 1170 PRTAASGPSS 1180 KLEKMPSIPE 1190 EPEHGDLERL 1200 SIPDFLRPLQ 1210 DLEVGLAKEA 1220 MLECQVTGLP 1230 YPTISWFHNG 1240 HRIQSSDDRR 1250 MTQYRDIHRL 1260 VFPAVGPQHA 1270 GVYKSVIANK 1280 LGKAACYAHL 1290 YVTDVVPGPP 1300 DGAPEVVAVT 1310 GRMVTLSWNP 1320 PRSLDMAIDP 1330 DSLTYTVQHQ 1340 VLGSDQWTAL 1350 VTGLREPAWA 1360 ATGLKKGIQH 1370 IFRVLSSSGK 1380 SSSKPSAPSE 1390 PVQLLEHGPP 1400 LEEAPAVLDK 1410 QDIVYVVEGQ 1420 PACVTVTFNH 1430 VEAQVVWRSC 1440 RGALLEARTG 1450 VYELSQPDDD 1460 QYCLRICRVS 1470 RRDLGPLTCS 1480 ARNRHGTKAC 1490 SVTLELAEAP 1500 RFESIMEDVE 1510 VGPGETARFA 1520 VVVEGKPLPD 1530 IMWYKDEVLL 1540 AESNHVSFVY 1550 EENECSLVLL 1560 SAGSQDGGVY 1570 TCTARNLAGE 1580 VSCKAELSVL 1590 SAQTAMEVEG 1600 VGEDEEHRGR 1610 RLSDYYDIHQ 1620 EIGRGAFSYL 1630 RRVVERSSGL 1640 EFAAKFIPSQ 1650 AKPKASARRE 1660 ARLLARLQHG 1670 CVLYFHEAFE 1680 RRRGLVIVTE 1690 LCTEELLERM 1700 ARKPTVCESE 1710 TRTYMRQVLE 1720 GICYLHQSHV 1730 LHLDVKPENL 1740 LVWDGAGGEE 1750 QVRICDFGNA 1760 QELTPGEPQY 1770 CQYGTPEFVA 1780 PEIVNQSPVS 1790 GVTDIWPVGV 1800 VAFLCLTGIS 1810 PFVGENDRTT 1820 LMNIRNYNVA 1830 FEETTFLSLS 1840 REARGFLIKV 1850 LVQDRLRPTA 1860 EETLEHPWFK 1870 TEAKGAEVST 1880 DHLKLFLSRR 1890 RWQRSQISYK 1900 CHLVLRPIPE 1910 LLRAPPERVW 1920 VAMPRRQPPS 1930 GGLSSSSDSE 1940 EEELEELPSV 1950 PRPLQPEFSG 1960 SRVSLTDIPT 1970 EDEALGTPEA 1980 GAATPMDWQE 1990 QERTPSKDQE 2000 APSPEALPSP 2010 GQESPDGPSP 2020 RRPELRRGSS 2030 AESALPRVGS 2040 REPGRSLHKA 2050 ASVELPQRRS 2060 PSPGATRLTR 2070 GGLGEGEYAQ 2080 RLQALRQRLL 2090 RGGPEDGKVS 2100 GLRGPLLESL 2110 GGRARDPRMA 2120 RAASSEAAPH 2130 HQPPPESRGL 2140 QKSSSFSQGE 2150 AEPRGRHRRA 2160 GAPLEIPVAR 2170 LGARRLQESP 2180 SLSALSETQP 2190 PSPARPSVPK 2200 LSITKSPEPS 2210 AVTSRDSPQP 2220 PEPQPVPEKV 2230 PEPKPEPVRA 2240 AKPAQPPLAL 2250 QMPTQPLTPY 2260 AQIMQSLQLS 2270 SPTLSPQDPA 2280 VPPSEPKPHA 2290 AVFARVASPP 2300 PGVSEKRVPS 2310 ARTPPVLAEK 2320 ARVPTVPPRP 2330 GSSLSGSIEN 2340 LESEAVFEAK 2350 FKRSRESPLS 2360 RGLRLLSRSR 2370 SEERGPFRGA 2380 EDDGIYRPSP 2390 AGTPLELVRR 2400 PERSRSVQDL 2410 RVAGEPGLVR 2420 RLSLSLSQKL 2430 RRTPPGQRHP 2440 AWESRSGDGE 2450 SSEGGSSARA 2460 SPVLAVRRRL 2470 SSTLERLSSR 2480 LQRSGSSEDS 2490 GGASGRSTPL 2500 FGRLRRATSE 2510 GESLRRLGVP 2520 HNQLGSQTGA 2530 TTPSAESLGS 2540 EASGTSGSSA 2550 PGESRSRHRW 2560 GLSRLRKDKG 2570 LSQPNLSSSV 2580 QEDLGHQYVP 2590 SESDFPPVFH 2600 IKLKDQVLLE 2610 GEAATLLCLP 2620 AACPAPRISW 2630 MKDKQSLRSE 2640 PSVVIVSCKD 2650 GRQLLSIPRA 2660 GKRHAGLYEC 2670 SATNVLGSIT 2680 SSCTVAVARI 2690 PGKLAPPEVP 2700 QTYHDTALVV 2710 WKPGDGRAPC 2720 TYTLERRVDG 2730 ESVWHPVSSG 2740 IPDCYYNVTQ 2750 LPVGVTVRFR 2760 VACSNRAGQG 2770 PFSNPSEKVF 2780 IRGTPDSPAQ 2790 PAAAPRDAPV 2800 TSGPTRAPPP 2810 DSPTSLAPTP 2820 ALAPPASQAS 2830 TLSPSTSSMS 2840 ANQALSSLKA 2850 VGPPPATPPR 2860 KHRGLLATQQ 2870 AEPSPPSIVV 2880 TPSEPRSFVP 2890 DTGTLTPTSS 2900 PQGVKPAPSS 2910 TSLYMVTSFV 2920 SAPPAPQAPA 2930 PEPPPEPTKV 2940 TVRSLSPAKE 2950 VVSSPTPEST 2960 TLRQGPPQKP 2970 YTFLEEKARG 2980 RFGVVRSCRE 2990 NATGRTFVAK 3000 IVPYAAEGKR 3010 RVLQEYEVLR 3020 TLHHERLMSL 3030 HEAYITPRYL 3040 VLIAESCGNR 3050 ELLCGLSDRF 3060 RYSEDDVATY 3070 VVQLLQGLDY 3080 LHGHHVLHLD 3090 IKPDNLLLAA 3100 DNALKIVDFG 3110 SAQPYNPQAL 3120 KPLGHRTGTL 3130 EFMAPEMVKG 3140 DPIGSATDIW 3150 GAGVLTYIML 3160 SGYSPFYEPD 3170 PQETEARIVG 3180 GRFDAFQLYP 3190 NTSQSATLFL 3200 RKVLSVHPWS 3210 RPSLQDCLAH 3220 PWLQDAYLMK 3230 LRRQTLTFTT 3240 NRLKEFLGEQ 3250 RRRRAEAATR 3260 HKVLLRSYPG SP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004672 protein kinase activity
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Biological Process GO:0055013 cardiac muscle cell development
Biological Process GO:0072359 circulatory system development
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0042692 muscle cell differentiation
Biological Process GO:0060541 respiratory system development

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.