Search Results
Overview
| Uniprot ID | Q62417 |
|---|---|
| Protein Name | Sorbin and SH3 domain-containing protein 1 |
| Gene Name | Sorbs1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 269 | PLSVPRSKSEMNYIE |
| 297 | PARSSSLKSSPERND |
| 331 | IYEYQPGKSSVLTNE |
| 37 | PTKICTGKGTVTLRA |
Function
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions
Protein Sequence
10
MSSECDVGSS
20
KAVVNGLASG
30
NHGPDKDMDP
40
TKICTGKGTV
50
TLRASSSYRG
60
TPSSSPVSPQ
70
ESPKHESKSG
80
LEPEDPSADE
90
WKLSSSADTN
100
GNAQPSPLAA
110
KGYRSVHPSL
120
SADKPQGSPL
130
LNEVSSSHIE
140
TDSQDFPPTS
150
RPSSAYPSTT
160
IVNPTIVLLQ
170
HNRDPASERR
180
AGEQDPVPTP
190
AELTSPGRAS
200
ERRAKDASRR
210
VVRSAQDLSD
220
VSTDEVGIPL
230
RNTERSKDWY
240
KTMFKQIHKL
250
NRDDDSDVHS
260
PRYSFSDDTK
270
SPLSVPRSKS
280
EMNYIEGEKV
290
VKRSATLPLP
300
ARSSSLKSSP
310
ERNDWEPLDK
320
KVDTRKYRAE
330
PKSIYEYQPG
340
KSSVLTNEKM
350
SRDISPEEID
360
LKNEPWYKFF
370
SELEFGRPTN
380
LEKDLSFCQA
390
ELEADLEKVE
400
TVNKSPSANS
410
PQSSAVSPTP
420
DITSEPPGYI
430
YSSNFHAVKR
440
ESDGTPGGLA
450
SLENERQIYK
460
SVLEGGDIPL
470
QGLSGLKRPS
480
SSASTKVDRK
490
GGNAHMISSS
500
SVHSRTFHTS
510
NALGPGCKHK
520
KPLSAAKACI
530
SEILPSKFKP
540
RLSAPSALLQ
550
EQKSVLLPSE
560
KAQSCENLCV
570
SLNDSKRGLP
580
LRVGGSIENL
590
LMRSRRDYDS
600
KSSSTMSLQE
610
YGTSSRRPCP
620
LSRKAGLHFS
630
MFYRDMHQIN
640
RAGLSLGSIS
650
SSSVRDLASH
660
FERSSLTLAR
670
GELGASQEGS
680
EHIPKHTVSS
690
RITAFEQLIQ
700
RSRSMPSLDF
710
SGRLSKSPTP
720
VLSRSGLTSA
730
RSAESLLEST
740
KLRPREMDGM
750
DSGGVYASPT
760
CSNMADHALS
770
FRSLVPSEPL
780
SICSDELDHC
790
SNVSNDSREG
800
SGGSVHGDFP
810
KHRLNKCKGT
820
CPASYTRFTT
830
IRKHEQQSSR
840
QSDWRSDSRG
850
DKNSLLRNIH
860
LMSPLPFRLK
870
KPLQQHPRQP
880
PPSDSSESPA
890
GQKADLPCHD
900
PQDQPHSAGK
910
PQVPTRLSSR
920
HTMARLSHNS
930
EPPLDRPAGL
940
EDCTRAINNG
950
NPVPYSDHGL
960
DRNNNPQSEL
970
AAAHGDSESP
980
RHFIPADYLE
990
STEEFIRRRH
1000
DDKEKLLADQ
1010
RRLKREQEEA
1020
DIAARRHTGV
1030
IPTHHQFITN
1040
ERFGDLLNID
1050
DTAKRKSGLE
1060
MRPARAKFDF
1070
KAQTLKELPL
1080
QKGDVVYIYR
1090
QIDQNWYEGE
1100
HHGRVGIFPR
1110
TYIELLPPAE
1120
KAQPRKLAPV
1130
QVLEYGEAIA
1140
KFNFNGDTQV
1150
EMSFRKGERI
1160
TLLRQVDENW
1170
YEGRIPGTSR
1180
QGIFPITYVD
1190
VLKRPLVKTP
1200
VDYIDLPYSS
1210
SPSRSATVSP
1220
QQPQAQQRRV
1230
TPDRSQPSLD
1240
LCSYQALYSY
1250
VPQNDDELEL
1260
RDGDIVDVME
1270
KCDDGWFVGT
1280
SRRTRQFGTF
1290
PGNYVKPLYL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0005158 | insulin receptor binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030159 | signaling receptor complex adaptor activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0095500 | acetylcholine receptor signaling pathway |
| Biological Process | GO:0031589 | cell-substrate adhesion |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0048041 | focal adhesion assembly |
| Biological Process | GO:0008286 | insulin receptor signaling pathway |
| Biological Process | GO:0046326 | positive regulation of D-glucose import across plasma membrane |
| Biological Process | GO:0045725 | positive regulation of glycogen biosynthetic process |
| Biological Process | GO:0046628 | positive regulation of insulin receptor signaling pathway |
| Biological Process | GO:0046889 | positive regulation of lipid biosynthetic process |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:1904393 | regulation of skeletal muscle acetylcholine-gated channel clustering |
| Biological Process | GO:0043149 | stress fiber assembly |
| Cellular Component | GO:0030055 | cell-substrate junction |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016600 | flotillin complex |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001725 | stress fiber |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.