Overview
| Uniprot ID | Q62418 |
|---|
| Protein Name | Drebrin-like protein |
|---|
| Gene Name | Dbnl |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 288 |
VTSSQPGKLRSPFLQ |
Function
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes
Protein Sequence
10
MAVNLSRNGP
20
ALQEAYVRVV
30
TEKSPTDWAL
40
FTYEGNSNDI
50
RVAGTGEGGL
60
EELVEELNSG
70
KVMYAFCRVK
80
DPNSGLPKFV
90
LINWTGEGVN
100
DVRKGACANH
110
VSTMANFLKG
120
AHVTINARAE
130
EDVEPECIME
140
KVAKASGANY
150
SFHKESTSFQ
160
DVGPQAPVGS
170
VYQKTNAISE
180
IKRVGKDNFW
190
AKAEKEEENR
200
RLEEKRRAEE
210
ERQRLEEERR
220
ERELQEAARR
230
EQRYQEQHRS
240
AGAPSPSSRT
250
GEPEQEAVSR
260
TRQEWESAGQ
270
QAPHPREIFK
280
QKERAMSTTS
290
VTSSQPGKLR
300
SPFLQKQLTQ
310
PETSYGREPT
320
APVSRPAAGV
330
CEEPAPSTLS
340
SAQTEEEPTY
350
EVPPEQDTLY
360
EEPPLVQQQG
370
AGSEHIDNYM
380
QSQGFSGQGL
390
CARALYDYQA
400
ADDTEISFDP
410
ENLITGIEVI
420
DEGWWRGYGP
430
DGHFGMFPAN
YVELIE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005938 |
cell cortex |
| Cellular Component |
GO:0030665 |
clathrin-coated vesicle membrane |
| Cellular Component |
GO:0030864 |
cortical actin cytoskeleton |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0043204 |
perikaryon |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0002102 |
podosome |
| Cellular Component |
GO:0098794 |
postsynapse |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Cellular Component |
GO:0045211 |
postsynaptic membrane |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0001726 |
ruffle |
| Cellular Component |
GO:0030427 |
site of polarized growth |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0019904 |
protein domain specific binding |
| Molecular Function |
GO:0098973 |
structural constituent of postsynaptic actin cytoskeleton |
| Biological Process |
GO:0002250 |
adaptive immune response |
| Biological Process |
GO:0006897 |
endocytosis |
| Biological Process |
GO:0048812 |
neuron projection morphogenesis |
| Biological Process |
GO:0071800 |
podosome assembly |
| Biological Process |
GO:0045773 |
positive regulation of axon extension |
| Biological Process |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
| Biological Process |
GO:0098974 |
postsynaptic actin cytoskeleton organization |
| Biological Process |
GO:0016601 |
Rac protein signal transduction |
| Biological Process |
GO:0030833 |
regulation of actin filament polymerization |
| Biological Process |
GO:0007416 |
synapse assembly |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.