Overview
| Uniprot ID | Q62599 |
|---|
| Protein Name | Metastasis-associated protein MTA1 |
|---|
| Gene Name | Mta1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 614 |
RNLLLNGKSYPTKVR |
Function
Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (By similarity). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (By similarity). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (By similarity). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (By similarity). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (By similarity). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity)
Protein Sequence
10
MAANMYRVGD
20
YVYFENSSSN
30
PYLIRRIEEL
40
NKTANGNVEA
50
KVVCFYRRRD
60
ISSSLIALAD
70
KHATLSVCYR
80
AGPGADTGEE
90
GEVEEEVENP
100
EMVDLPEKLK
110
HQLRHRELFL
120
SRQLESLPAT
130
HIRGKCSVTL
140
LNETESLKSY
150
LEREDFFFYS
160
LVYDPQQKTL
170
LADKGEIRVG
180
NRYQADITDL
190
LKDGEEDGRD
200
QSKLETKVWE
210
AHNPLVDKQI
220
DQFLVVARSV
230
GTFARALDCS
240
SSVRQPSLHM
250
SAAAASRDIT
260
LFHAMDTLHK
270
NIYDISKAIS
280
ALVPQGGPVL
290
CRDEMEEWSA
300
SEANLFEEAL
310
EKYGKDFTDI
320
QQDFLPWKSL
330
TSIIEYYYMW
340
KTTDRYVQQK
350
RLKAAEAESK
360
LKQVYIPNYN
370
KPNPNQISVN
380
SVKASVVNGT
390
GTPGQSPGAG
400
RACESCYTTQ
410
SYQWYSWGPP
420
NMQCRLCASC
430
WTYWKKYGGL
440
KMPTRLDGER
450
PGPNRNNMSP
460
HGIPARSSGS
470
PKFAMKTRQA
480
FYLHTTKLTR
490
IARRLCREIL
500
RPWHAARHPY
510
MPINSAAIKA
520
ECTARLPEAS
530
QSPLVLKQVV
540
RKPLEAVLRY
550
LETHPRPPKP
560
DPVKSSSSVL
570
SSLTPAKSAP
580
VINNGSPTIL
590
GKRSYEQHNG
600
VDGLANHGQT
610
RHMGPSRNLL
620
LNGKSYPTKV
630
RLIRGGSLPP
640
VKRRRMNWID
650
APDDVFYMAT
660
EETRKIRKLL
670
SSSETKRAAR
680
RPYKPIALRQ
690
SQALPLRPPP
700
PAPVNDEPIV
IED
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0016581 |
NuRD complex |
| Cellular Component |
GO:0005791 |
rough endoplasmic reticulum |
| Cellular Component |
GO:0042588 |
zymogen granule |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0042826 |
histone deacetylase binding |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0061629 |
RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Molecular Function |
GO:0003714 |
transcription corepressor activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0032922 |
circadian regulation of gene expression |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006302 |
double-strand break repair |
| Biological Process |
GO:0043153 |
entrainment of circadian clock by photoperiod |
| Biological Process |
GO:0007565 |
female pregnancy |
| Biological Process |
GO:0045475 |
locomotor rhythm |
| Biological Process |
GO:0045814 |
negative regulation of gene expression, epigenetic |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:1902499 |
positive regulation of protein autoubiquitination |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0010212 |
response to ionizing radiation |
| Biological Process |
GO:0033363 |
secretory granule organization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.