Search Results
Overview
| Uniprot ID | Q62636 |
|---|---|
| Protein Name | Ras-related protein Rap-1b |
| Gene Name | Rap1b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | EDERVVGKEQGQNLA |
| 151 | LESSAKSKINVNEIF |
| 5 | ***MREYKLVVLGSG |
Function
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031045 | dense core granule |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0071320 | cellular response to cAMP |
| Biological Process | GO:1904322 | cellular response to forskolin |
| Biological Process | GO:0097211 | cellular response to gonadotropin-releasing hormone |
| Biological Process | GO:0061028 | establishment of endothelial barrier |
| Biological Process | GO:0030073 | insulin secretion |
| Biological Process | GO:0099010 | modification of postsynaptic structure |
| Biological Process | GO:0045955 | negative regulation of calcium ion-dependent exocytosis |
| Biological Process | GO:2000301 | negative regulation of synaptic vesicle exocytosis |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0033625 | positive regulation of integrin activation |
| Biological Process | GO:0032486 | Rap protein signal transduction |
| Biological Process | GO:1901888 | regulation of cell junction assembly |
| Biological Process | GO:2000114 | regulation of establishment of cell polarity |
| Biological Process | GO:0009743 | response to carbohydrate |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.