Search Results
Overview
| Uniprot ID | Q62658 |
|---|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase FKBP1A |
| Gene Name | Fkbp1a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 48 | RDRNKPFKFTLGKQE |
| 53 | PFKFTLGKQEVIRGW |
Function
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0005528 | FK506 binding |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0070411 | I-SMAD binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function | GO:0030547 | signaling receptor inhibitor activity |
| Molecular Function | GO:0005160 | transforming growth factor beta receptor binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0034713 | type I transforming growth factor beta receptor binding |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0019221 | cytokine-mediated signaling pathway |
| Biological Process | GO:0003007 | heart morphogenesis |
| Biological Process | GO:0060347 | heart trabecula formation |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0032926 | negative regulation of activin receptor signaling pathway |
| Biological Process | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:1902991 | regulation of amyloid precursor protein catabolic process |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:0050776 | regulation of immune response |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| Biological Process | GO:0051209 | release of sequestered calcium ion into cytosol |
| Biological Process | GO:0031000 | response to caffeine |
| Biological Process | GO:0010039 | response to iron ion |
| Biological Process | GO:0097435 | supramolecular fiber organization |
| Biological Process | GO:0042098 | T cell proliferation |
| Biological Process | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098562 | cytoplasmic side of membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:1990425 | ryanodine receptor complex |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0070697 | activin receptor binding |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.