Search Results
Overview
| Uniprot ID | Q62696 |
|---|---|
| Protein Name | Disks large homolog 1 |
| Gene Name | Dlg1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 667 | NSKTRGDKGEIPDDM |
Function
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel (By similarity). During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (By similarity)
Protein Sequence
10
MPVRKQDTQR
20
ALHLLEEYRS
30
KLSQTEDRQL
40
RSSIERVISI
50
FQSNLFQALI
60
DIQEFYEVTL
70
LDNPKCVDHS
80
KQCEPVQPGN
90
PWESGSLSSA
100
AVTSESLPGG
110
LSPPVEKYRY
120
QDEEVLPSER
130
ISPQVPNEVL
140
GPELVHVSEK
150
SLSEIENVHG
160
FVSHSHISPI
170
KPTEAVPPSS
180
PIVPVTPALP
190
VPAESPVVLP
200
STPQANPPPV
210
LVNTDSLETP
220
TYVNGTDADY
230
EYEEITLERG
240
NSGLGFSIAG
250
GTDNPHIGDD
260
SSIFITKIIT
270
GGAAAQDGRL
280
RVNDCILRVN
290
EADVRDVTHS
300
KAVEALKEAG
310
SIVRLYVKRR
320
KAFRKNHEIK
330
LIKGPKGLGF
340
SIAGGVGNQH
350
IPGDNSIYVT
360
KIIEGGAAHK
370
DGKLQIGDKL
380
LAVNSVCLEE
390
VTHEEAVTAL
400
KNTSDFVYLK
410
AAKPTSMYIN
420
DGYAPPDITN
430
SSSQSVDNHV
440
SPSSYLGQTP
450
ASPARYSPIS
460
KAVLGDDEIT
470
REPRKVVLHR
480
GSTGLGFNIV
490
GGEDGEGIFI
500
SFILAGGPAD
510
LSGELRKGDR
520
IISVNSVDLR
530
AASHEQAAAA
540
LKNAGQAVTI
550
VAQYRPEEYS
560
RFEAKIHDLR
570
ETMMNSSVSS
580
GSGSLRTSQK
590
RSLYVRALFD
600
YDKTKDSGLP
610
SQGLNFKFGD
620
ILHVINASDD
630
EWWQARQVTP
640
DGESDEVGVI
650
PSKRRVEKKE
660
RARLKTVKFN
670
SKTRGDKGEI
680
PDDMGSKGLK
690
HVTSNASDSE
700
SSYHEYGCSK
710
GGQEEYVLSY
720
EPVNQQEVNY
730
TRPVIILGPM
740
KDRVNDDLIS
750
EFPDKFGSCV
760
PHTTRPKRDY
770
EVDGRDYHFV
780
TSREQMEKDI
790
QEHKFIEAGQ
800
YNNHLYGTSV
810
QSVRAVAEKG
820
KHCILDVSGN
830
AIKRLQIAQL
840
YPISIFIKPK
850
SMENIMEMNK
860
RLTDEQARKT
870
FERAVRLEQE
880
FTEHFTAIVQ
890
GDTLEDIYNQ
900
VKQIIEEQSG
910
PYIWVPAKEK
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0009925 | basal plasma membrane |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0031253 | cell projection membrane |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0001772 | immunological synapse |
| Cellular Component | GO:0043219 | lateral loop |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0097025 | MPP7-DLG1-LIN7 complex |
| Cellular Component | GO:0035748 | myelin sheath abaxonal region |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0033268 | node of Ranvier |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0033270 | paranode region of axon |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0099092 | postsynaptic density, intracellular component |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0097060 | synaptic membrane |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0030315 | T-tubule |
| Molecular Function | GO:0035255 | ionotropic glutamate receptor binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0019894 | kinesin binding |
| Molecular Function | GO:0097016 | L27 domain binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0019902 | phosphatase binding |
| Molecular Function | GO:0015459 | potassium channel regulator activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0098919 | structural constituent of postsynaptic density |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0032147 | activation of protein kinase activity |
| Biological Process | GO:0042982 | amyloid precursor protein metabolic process |
| Biological Process | GO:0030953 | astral microtubule organization |
| Biological Process | GO:0070830 | bicellular tight junction assembly |
| Biological Process | GO:0001658 | branching involved in ureteric bud morphogenesis |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0030866 | cortical actin cytoskeleton organization |
| Biological Process | GO:0043622 | cortical microtubule organization |
| Biological Process | GO:0048704 | embryonic skeletal system morphogenesis |
| Biological Process | GO:0001935 | endothelial cell proliferation |
| Biological Process | GO:0010669 | epithelial structure maintenance |
| Biological Process | GO:0051660 | establishment of centrosome localization |
| Biological Process | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| Biological Process | GO:0060022 | hard palate development |
| Biological Process | GO:0001771 | immunological synapse formation |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0002088 | lens development in camera-type eye |
| Biological Process | GO:0031579 | membrane raft organization |
| Biological Process | GO:0098915 | membrane repolarization during ventricular cardiac muscle cell action potential |
| Biological Process | GO:0050680 | negative regulation of epithelial cell proliferation |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:1903753 | negative regulation of p38MAPK cascade |
| Biological Process | GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0042130 | negative regulation of T cell proliferation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0099645 | neurotransmitter receptor localization to postsynaptic specialization membrane |
| Biological Process | GO:0030432 | peristalsis |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0043268 | positive regulation of potassium ion transport |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0035418 | protein localization to synapse |
| Biological Process | GO:0031503 | protein-containing complex localization |
| Biological Process | GO:0043113 | receptor clustering |
| Biological Process | GO:0097120 | receptor localization to synapse |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0042391 | regulation of membrane potential |
| Biological Process | GO:0031641 | regulation of myelination |
| Biological Process | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| Biological Process | GO:1903764 | regulation of potassium ion export across plasma membrane |
| Biological Process | GO:1903286 | regulation of potassium ion import |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:1902473 | regulation of protein localization to synapse |
| Biological Process | GO:0098911 | regulation of ventricular cardiac muscle cell action potential |
| Biological Process | GO:0048608 | reproductive structure development |
| Biological Process | GO:0048745 | smooth muscle tissue development |
| Biological Process | GO:0042110 | T cell activation |
| Biological Process | GO:0048729 | tissue morphogenesis |
| Biological Process | GO:0001657 | ureteric bud development |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.