Search Results
Overview
| Uniprot ID | Q62733 |
|---|---|
| Protein Name | Lamina-associated polypeptide 2, isoform beta |
| Gene Name | Tmpo |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 17 | VLTKDKLKSELVANN |
| 202 | LEKREPLKGRAKTPV |
| 206 | EPLKGRAKTPVTLKQ |
| 212 | AKTPVTLKQRRIEHN |
| 238 | EWTSGSSKGGPLQAL |
| 302 | NRLTGNFKHASSILP |
| 322 | DITRRTPKKPLTRAE |
| 388 | MEESFSSKYVPKYVP |
| 392 | FSSKYVPKYVPLADV |
Function
Binds directly to lamin B1 and chromosomes in a mitotic phosphorylation-regulated manner. May play an important role in nuclear envelope reassembly at the end of mitosis and/or anchoring of the nuclear lamina and interphase chromosomes to the nuclear envelope
Protein Sequence
10
MPEFLEDPSV
20
LTKDKLKSEL
30
VANNVTLPAG
40
EQRKDVYVQL
50
YLQHLTARNR
60
PPLAAGANSK
70
GPPDFSSDEE
80
REPTPVLGSG
90
ASVGRGRGAV
100
GRKATKKTDK
110
PRPEDKDDLD
120
VTELSNEELL
130
EQLVRYGVNP
140
GPIVGTTRKL
150
YEKKLLKLRE
160
QGAESRSSTP
170
LPTVSSSAEN
180
TRQNGSNDSD
190
RYSDNDEDSK
200
IELKLEKREP
210
LKGRAKTPVT
220
LKQRRIEHNQ
230
SYSEAGVTET
240
EWTSGSSKGG
250
PLQALTREST
260
RGSRRTPRRR
270
VEPSQHFRVD
280
GAVISESTPI
290
AETIKASSND
300
SLVANRLTGN
310
FKHASSILPI
320
TEFSDITRRT
330
PKKPLTRAEV
340
GEKTEERRVE
350
RDILKEMFPY
360
EASTPTGISA
370
SCRRPIKGAA
380
GRPLELSDFR
390
MEESFSSKYV
400
PKYVPLADVK
410
SEKTKKGRSV
420
PMWIKMLLFA
430
LVAGFLFLVY
440
QAMETNQGNP
450
FTNFLQDTKI
SN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005637 | nuclear inner membrane |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005521 | lamin binding |
| Biological Process | GO:0031468 | nuclear membrane reassembly |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.