Overview
| Uniprot ID | Q62760 |
|---|
| Protein Name | Mitochondrial import receptor subunit TOM20 homolog |
|---|
| Gene Name | Tomm20 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 56 |
KERAGLSKLPDLKDA |
Function
Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with TOMM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (PubMed:19401463)
Protein Sequence
10
MVGRNSAIAA
20
GVCGALFIGY
30
CIYFDRKRRS
40
DPNFKNRLRE
50
RRKKQKLAKE
60
RAGLSKLPDL
70
KDAEAVQKFF
80
LEEIQLGEEL
90
LAQGDYEKGV
100
DHLTNAIAVC
110
GQPQQLLQVL
120
QQTLPPPVFQ
130
MLLTKLPTIS
140
QRIVSAQSLA
EDDVE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071944 |
cell periphery |
| Cellular Component |
GO:0140494 |
migrasome |
| Cellular Component |
GO:0044233 |
mitochondria-associated endoplasmic reticulum membrane contact site |
| Cellular Component |
GO:0005740 |
mitochondrial envelope |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005742 |
mitochondrial outer membrane translocase complex |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0097225 |
sperm midpiece |
| Molecular Function |
GO:0030943 |
mitochondrion targeting sequence binding |
| Molecular Function |
GO:0015450 |
protein-transporting ATPase activity |
| Molecular Function |
GO:0051082 |
unfolded protein binding |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0030150 |
protein import into mitochondrial matrix |
| Biological Process |
GO:0006626 |
protein targeting to mitochondrion |
| Biological Process |
GO:1905242 |
response to 3,3',5-triiodo-L-thyronine |
| Biological Process |
GO:0014850 |
response to muscle activity |
| Biological Process |
GO:0016031 |
tRNA import into mitochondrion |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.