Search Results
Overview
| Uniprot ID | Q62768 |
|---|---|
| Protein Name | Protein unc-13 homolog A |
| Gene Name | Unc13a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1456 | LGQLSKLKDHMVREE |
| 400 | AAPQKEDKVSAVPIE |
| 706 | QGLQAKDKTGSSDPY |
Function
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity)
Protein Sequence
10
MSLLCVGVKK
20
AKFDGAQEKF
30
NTYVTLKVQN
40
VKSTTIAVRG
50
SQPSWEQDFM
60
FEINRLDLGL
70
TVEVWNKGLI
80
WDTMVGTVWI
90
PLRTIRQSNE
100
EGPGEWLTLD
110
SQAIMADSEI
120
CGTKDPTFHR
130
ILLDAHFELP
140
LDIPEEEARY
150
WAKKLEQLNA
160
MRDQDEYSFQ
170
DQQDKPLPVP
180
SSQCCNWNYF
190
GWGEQNDDPD
200
SAVDDRDSDY
210
RSETSNSIPP
220
PYYTTSQPNA
230
SVHQYSVRPP
240
PLGSRESYSD
250
SMHSYEEFSE
260
PRALSPTGSS
270
RYASSGELSQ
280
GSSQLSEDFD
290
PDEHSLQGSE
300
LDDERDRDSY
310
HSCHSSVSYH
320
KDSPRWDQDE
330
EDLEDLEDLE
340
DEELPEEEEL
350
EEEELEEEEE
360
LEEEELELEE
370
EEEVPDDLAS
380
YTQQEDTTVA
390
EPKEFKRISF
400
PTAAPQKEDK
410
VSAVPIEAPD
420
VSKGIPKAAT
430
PEEKAAAECA
440
QEAEPPKSEE
450
SFRSREAEEG
460
QEGQDAMSRA
470
KANWLRAFNK
480
VRMQLQEARG
490
EGEMSKSLWF
500
KGGPGGGLII
510
IDSMPDIRKR
520
KPIPLVSDLA
530
MSLVQSRKAG
540
ITSALASSTL
550
NNEELKNHVY
560
KKTLQALIYP
570
ISCTTPHNFE
580
VWTATTPTYC
590
YECEGLLWGI
600
ARQGMRCTEC
610
GVKCHEKCQD
620
LLNADCLQRA
630
AEKSSKHGAE
640
DRTQNIIMVL
650
KDRMKIRERN
660
KPEIFELIQE
670
VFAVTKSAHT
680
QQMKAVKQSV
690
LDGTSKWSAK
700
ISITVVCAQG
710
LQAKDKTGSS
720
DPYVTVQVGK
730
TKKRTKTIYG
740
NLNPVWEENF
750
HFECHNSSDR
760
IKVRVLDEDD
770
DIKSRVKQRF
780
KRESDDFLGQ
790
TIIEVRTLSG
800
EMDVWYNLDK
810
RTDKSAVSGA
820
IRLHISVEIK
830
GEEKVAPYHV
840
QYTCLHENLF
850
HFVTDVQNNG
860
VVKIPDAKGD
870
DAWKVYYDET
880
AQEIVDEFAM
890
RYGVESIYQA
900
MTHFACLSSK
910
YMCPGVPAVM
920
STLLANINAY
930
YAHTTASTNV
940
SASDRFAASN
950
FGKERFVKLL
960
DQLHNSLRID
970
LSMYRNNFPA
980
SSPERLQDLK
990
STVDLLTSIT
1000
FFRMKVQELQ
1010
SPPRASQVVK
1020
DCVKACLNST
1030
YEYIFNNCHE
1040
LYGREYQTDP
1050
AKKGEVPPEE
1060
QGPSIKNLDF
1070
WSKLITLIVS
1080
IIEEDKNSYT
1090
PCLNQFPQEL
1100
NVGKISAEVM
1110
WSLFAQDMKY
1120
AMEEHDKHRL
1130
CKSADYMNLH
1140
FKVKWLYNEY
1150
VAELPTFKDR
1160
VPEYPAWFEP
1170
FVIQWLDENE
1180
EVSRDFLHGA
1190
LERDKKDGFQ
1200
QTSEHALFSC
1210
SVVDVFSQLN
1220
QSFEIIKKLE
1230
CPDPQIVGHY
1240
MRRFAKTISN
1250
VLLQYADIVS
1260
KDFASYCSKE
1270
KEKVPCILMN
1280
NTQQLRVQLE
1290
KMFEAMGGKE
1300
LDAEASGTLK
1310
ELQVKLNNVL
1320
DELSHVFATS
1330
FQPHIEECVR
1340
QMGDILSQVK
1350
GTGNVPASAC
1360
SSVAQDADNV
1370
LQPIMDLLDS
1380
NLTLFAKICE
1390
KTVLKRVLKE
1400
LWKLVMNTME
1410
RTIVLPPLTD
1420
QTMIGTLLRK
1430
HGKGLEKGRV
1440
KLPSHSDGTQ
1450
MIFNAAKELG
1460
QLSKLKDHMV
1470
REEAKSLTPK
1480
QCAVVELALD
1490
TIKQYFHAGG
1500
VGLKKTFLEK
1510
SPDLQSLRYA
1520
LSLYTQATDL
1530
LIKTFVQTQS
1540
AQVHGGKGTR
1550
FTLSEDVCPE
1560
MGSGVEDPVG
1570
EVSVHVELFT
1580
HPGTGEQKVT
1590
VKVVAANDLK
1600
WQTSGIFRPF
1610
IEVNIVGPQL
1620
SDKKRKFATK
1630
SKNNSWAPKY
1640
NESFQFSLSA
1650
DAGPECYELQ
1660
VCVKDYCFAR
1670
EDRTVELAVL
1680
QLRELAQRGS
1690
AACWLPLGRR
1700
IHMDDTGLTV
1710
LRILSQRSND
1720
EVAKEFVKLK
1730
SDTRSAEEGG
AAPAP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0044305 | calyx of Held |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005798 | Golgi-associated vesicle |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0097060 | synaptic membrane |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0019992 | diacylglycerol binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0030507 | spectrin binding |
| Molecular Function | GO:0019905 | syntaxin binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0050435 | amyloid-beta metabolic process |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0061789 | dense core granule priming |
| Biological Process | GO:0060384 | innervation |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0007528 | neuromuscular junction development |
| Biological Process | GO:0099011 | neuronal dense core vesicle exocytosis |
| Biological Process | GO:0007269 | neurotransmitter secretion |
| Biological Process | GO:1903861 | positive regulation of dendrite extension |
| Biological Process | GO:1900451 | positive regulation of glutamate receptor signaling pathway |
| Biological Process | GO:0001956 | positive regulation of neurotransmitter secretion |
| Biological Process | GO:0031915 | positive regulation of synaptic plasticity |
| Biological Process | GO:0031340 | positive regulation of vesicle fusion |
| Biological Process | GO:1902991 | regulation of amyloid precursor protein catabolic process |
| Biological Process | GO:0150037 | regulation of calcium-dependent activation of synaptic vesicle fusion |
| Biological Process | GO:0048172 | regulation of short-term neuronal synaptic plasticity |
| Biological Process | GO:0010807 | regulation of synaptic vesicle priming |
| Biological Process | GO:0035493 | SNARE complex assembly |
| Biological Process | GO:0035249 | synaptic transmission, glutamatergic |
| Biological Process | GO:0016081 | synaptic vesicle docking |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Biological Process | GO:0016188 | synaptic vesicle maturation |
| Biological Process | GO:0016082 | synaptic vesicle priming |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.