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Overview

Uniprot IDQ62806
Protein NameZinc finger protein 148
Gene NameZnf148
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
225 EKIHTGEKPFRCDEC
424 YEDSKVSKYAFELVD

Function

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes

Protein Sequence

10 MNIDDKLEGL 20 FLKCGGIDEM 30 QSSRAMVVMG 40 GVSGQSAVSG 50 ELQESVLQDR 60 SLPHQEILAA 70 DEVLQESEMR 80 QQDMISHDEL 90 MVHEETVKND 100 EEQTDTHERL 110 PQGLQYALNV 120 PISVKQEITF 130 TDVSEQLMRD 140 KKQVREPVDL 150 QKKKKRKQRS 160 PAKILTINED 170 GSLGLKTPKS 180 HVCEHCNAAF 190 RTNYHLQRHV 200 FIHTGEKPFQ 210 CSQCDMRFIQ 220 KYLLQRHEKI 230 HTGEKPFRCD 240 ECGMRFIQKY 250 HMERHKRTHS 260 GEKPYQCEYC 270 LQYFSRTDRV 280 LKHKRMCHEN 290 HDKKLNRCAI 300 KGGLLTSEED 310 SGFSTSPKDN 320 SLPKKKRQKP 330 EKKSSGMDKE 340 SVLDKSDTKK 350 DRNDYLPLYS 360 SSTKVKDEYM 370 VAEYAVEMPH 380 SSVGGSHLED 390 ASGEIHPPKL 400 VLKKINSKRS 410 LKQPLEQSQT 420 ISPLSTYEDS 430 KVSKYAFELV 440 DKQALLDSEG 450 SADIDQVDNL 460 QEGPSKPVHS 470 STNYDDAMQF 480 LKKKRYLQAA 490 SNNSREYALN 500 VGTIASQPSV 510 TQAAVASVID 520 ENTTASILDS 530 QALNVEIKSN 540 HDKNVIPDEV 550 LQTLLDHYSH 560 KANGQHEISF 570 SVADTEVTSS 580 ISINSSDVPE 590 VTQSENVGSS 600 SQASSSDKAN 610 MLQEYSKFLQ 620 QALDRTSQND 630 AYLNSPSLNF 640 VTDNQTLPNP 650 PAFSSIDKQV 660 YAAMPINSFR 670 SGMNSPLRTT 680 PDKSHFGLIV 690 GDSQHPFPFS 700 GDETNHASAT 710 STADFLDQVT 720 SQKKAEAQPV 730 HQAYQMSSFE 740 QPFRAPYHGS 750 RAGIATQFST 760 ANGQVNLRGP 770 GTSAEFSEFP 780 LVNVNDNRAG 790 MTSSPDATTG QTFG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.