Search Results
Overview
| Uniprot ID | Q62868 |
|---|---|
| Protein Name | Rho-associated protein kinase 2 |
| Gene Name | Rock2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1368 | SSPRTSMKIQQNQSI |
| 720 | ARLADKNKIYESIEE |
Function
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays a role in placental homeostasis during the perinatal period. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation
Protein Sequence
10
MSRPPPTGKM
20
PGAPEAAAGD
30
GAGAGRQRKL
40
EALIRDPRSP
50
INVESLLDGL
60
NSLVLDLDFP
70
ALRKNKNIDN
80
FLNRYEKIVK
90
KIRGLQMKAE
100
DYDVVKVIGR
110
GAFGEVQLVR
120
HKASQKVYAM
130
KLLSKFEMIK
140
RSDSAFFWEE
150
RDIMAFANSP
160
WVVQLFCAFQ
170
DDRYLYMVME
180
YMPGGDLVNL
190
MSNYDVPEKW
200
AKFYTAEVVL
210
ALDAIHSMGL
220
IHRDVKPDNM
230
LLDKHGHLKL
240
ADFGTCMKMD
250
ETGMVHCDTA
260
VGTPDYISPE
270
VLKSQGGDGY
280
YGRECDWWSV
290
GVFLFEMLVG
300
DTPFYADSLV
310
GTYSKIMDHK
320
NSLCFPEDTE
330
ISKHAKNLIC
340
AFLTDREVRL
350
GRNGVEEIKS
360
ASFFKNDQWN
370
WDNIRETAAP
380
VVPELSSDID
390
SSNFDDIEDD
400
KGDVETFPIP
410
KAFVGNQLPF
420
IGFTYFRENL
430
LLSDSPPCRE
440
NDAIQTRKSE
450
ESQEIQKKLY
460
ALEEHLSSEV
470
QAKEELEQKC
480
KSINTRLEKT
490
AKELEEEITF
500
RKNVESTLRQ
510
LEREKALLQH
520
KNAEYQRKAD
530
HEADKKRNLE
540
NDVNSLKDQL
550
EDLKKRNQSS
560
QISTEKVNQL
570
QKQLDEANAL
580
LRTESDTAAR
590
LRKTQAESSK
600
QIQQLESNNR
610
DLQDKNCLLE
620
TAKLKLEKEF
630
INLQSALESE
640
RRDRTHGSEI
650
INDLQGRISG
660
LEEDLKTGKT
670
LLAKVELEKR
680
QLQEKLTDLE
690
KEKSNMEIDM
700
TYQLKVIQQS
710
LEQEEAEHKT
720
TKARLADKNK
730
IYESIEEAKS
740
EAMKEMEKKL
750
LEERSLKQKV
760
ENLLLEAEKR
770
CSILDCDLKQ
780
SQQKLNELLK
790
QKDVLNEDVR
800
NLTLKIEQET
810
QKRCLMQNDL
820
KMQTQQVNTL
830
KMSEKQIKQE
840
NNHLMEMKMN
850
LEKQNAELRK
860
ERQDADGQMK
870
ELQDQLEAEQ
880
YFSTLYKTQV
890
RELKEENEEK
900
TKLCKELQQK
910
KQDLQDERDS
920
LAAQLEITLT
930
KADSEQLARS
940
IAEEQYSDLE
950
KEKIMKELEI
960
KEMMARHKQE
970
LTEKDATIAS
980
LEETNRTLTS
990
DVANLANEKE
1000
ELNNKLKDTQ
1010
EQLSKLKDEE
1020
ISAAAIKAQF
1030
EKQLLTERTL
1040
KTQAVNKLAE
1050
IMNRKEPVKR
1060
GSDTDVRRKE
1070
KENRKLHMEL
1080
KSEREKLTQQ
1090
MIKYQKELNE
1100
MQAQIAEESQ
1110
IRIELQMTLD
1120
SKDSDIEQLR
1130
SQLQALHIGM
1140
DSSSIGSGPG
1150
DAEPDDGFPE
1160
SRLEGWLSLP
1170
VRNNTKKFGW
1180
VKKYVIVSSK
1190
KILFYDSEQD
1200
KEQSNPYMVL
1210
DIDKLFHVRP
1220
VTQTDVYRAD
1230
AKEIPRIFQI
1240
LYANEGESKK
1250
EPEFPVEPVG
1260
EKSNYICHKG
1270
HEFIPTLYHF
1280
PTNCEACMKP
1290
LWHMFKPPPA
1300
LECSRCHIKC
1310
HKDHMDKKEE
1320
IIAPCKVYYD
1330
ISSAKNLLLL
1340
ANSTEEQQKW
1350
VSRLVKKIPK
1360
KPPAPDPFAR
1370
SSPRTSMKIQ
1380
QNQSIRRPSR
QLAPNKPS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:1903140 | regulation of establishment of endothelial barrier |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0031616 | spindle pole centrosome |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0061133 | endopeptidase activator activity |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0072518 | Rho-dependent protein serine/threonine kinase activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0031032 | actomyosin structure organization |
| Biological Process | GO:0003180 | aortic valve morphogenesis |
| Biological Process | GO:0097746 | blood vessel diameter maintenance |
| Biological Process | GO:1905145 | cellular response to acetylcholine |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0051298 | centrosome duplication |
| Biological Process | GO:0030261 | chromosome condensation |
| Biological Process | GO:0030866 | cortical actin cytoskeleton organization |
| Biological Process | GO:0048813 | dendrite morphogenesis |
| Biological Process | GO:0048598 | embryonic morphogenesis |
| Biological Process | GO:0001837 | epithelial to mesenchymal transition |
| Biological Process | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0061157 | mRNA destabilization |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:1903347 | negative regulation of bicellular tight junction assembly |
| Biological Process | GO:0070168 | negative regulation of biomineral tissue development |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0045019 | negative regulation of nitric oxide biosynthetic process |
| Biological Process | GO:0150033 | negative regulation of protein localization to lysosome |
| Biological Process | GO:0001843 | neural tube closure |
| Biological Process | GO:1902993 | positive regulation of amyloid precursor protein catabolic process |
| Biological Process | GO:1902004 | positive regulation of amyloid-beta formation |
| Biological Process | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0010825 | positive regulation of centrosome duplication |
| Biological Process | GO:0032723 | positive regulation of connective tissue growth factor production |
| Biological Process | GO:1905205 | positive regulation of connective tissue replacement |
| Biological Process | GO:0090271 | positive regulation of fibroblast growth factor production |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:1902966 | positive regulation of protein localization to early endosome |
| Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:0098974 | postsynaptic actin cytoskeleton organization |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0110061 | regulation of angiotensin-activated signaling pathway |
| Biological Process | GO:1901888 | regulation of cell junction assembly |
| Biological Process | GO:1900037 | regulation of cellular response to hypoxia |
| Biological Process | GO:0042752 | regulation of circadian rhythm |
| Biological Process | GO:0045616 | regulation of keratinocyte differentiation |
| Biological Process | GO:0031644 | regulation of nervous system process |
| Biological Process | GO:0090128 | regulation of synapse maturation |
| Biological Process | GO:1990776 | response to angiotensin |
| Biological Process | GO:0002931 | response to ischemia |
| Biological Process | GO:0071559 | response to transforming growth factor beta |
| Biological Process | GO:0007266 | Rho protein signal transduction |
| Biological Process | GO:0048511 | rhythmic process |
| Biological Process | GO:0006939 | smooth muscle contraction |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.