Search Results

Overview

Uniprot IDQ62910
Protein NamePolyphosphatidylinositol phosphatase SYNJ1
Gene NameSynj1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1137 RSPAPARKEFGGVGA
1223 LTPESQSKPLETSKG
169 QSLHLHLKHYGVNCD
346 VKGGKAEKLHSVLKP
449 GTGALEGKAKLKDGA
515 TLQSASSKVLKNMCE
577 GIQEFQDKRSKPTDI

Function

Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner (PubMed:8552192, PubMed:9710239). The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (PubMed:8552192, PubMed:9710239). The SAC domain hydrolyzes phosphates at the 3- and 4-positions of the inositol ring, targeting phosphatidylinositol-3-phosphate (PI(3)P), phosphatidylinositol-4-phosphate (PI(4)P), and phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) (By similarity). Plays a role in the phosphatidylinositol metabolic process during an unconventional endocytic mechanism, the ultrafast endocytosis where it participates in the rapide neck formation of the newly generated synaptic vesicle through its phosphoinositide 5-phosphatase activity (By similarity). Also, participates in the clathrin uncoating of synaptc vesicle formed via budding from synaptic endosomes after ultrafast endocytosis through combined activity of its phosphatase domains (PubMed:9428629). Additionally, regulates actin filament rearrangement by hydrolyzing PIP2 bound to actin regulatory proteins (By similarity)

Protein Sequence

10 MAFSKGFRIY 20 HKLDPPPFSL 30 IVETRHKEEC 40 LMFESGAVAV 50 LSSAEKEAIK 60 GTYAKVLDAY 70 GLLGVLRLNL 80 GDTMLHYLVL 90 VTGCMSVGKI 100 QESEVFRVTS 110 TEFISLRVDA 120 SDEDRISEVR 130 KVLNSGNFYF 140 AWSASGVSLD 150 LSLNAHRSMQ 160 EHTTDNRFFW 170 NQSLHLHLKH 180 YGVNCDDWLL 190 RLMCGGVEIR 200 TIYAAHKQAK 210 ACLISRLSCE 220 RAGTRFNVRG 230 TNDDGHVANF 240 VETEQVIYLD 250 DCVSSFIQIR 260 GSVPLFWEQP 270 GLQVGSHRVR 280 MSRGFEANAP 290 AFDRHFRTLK 300 DLYGKQIVVN 310 LLGSKEGEHM 320 LSKAFQSHLK 330 ASEHASDIHM 340 VSFDYHQMVK 350 GGKAEKLHSV 360 LKPQVQKFLD 370 YGFFYFDGSA 380 VQRCQSGTVR 390 TNCLDCLDRT 400 NSVQAFLGLE 410 MLAKQLEALG 420 LAEKPQLVTR 430 FQEVFRSMWS 440 VNGDSISKIY 450 AGTGALEGKA 460 KLKDGARSVT 470 RTIQNNFFDS 480 SKQEAIDVLL 490 LGNTLNSDLA 500 DKARALLTTG 510 SLRVSEQTLQ 520 SASSKVLKNM 530 CENFYKYSKP 540 KKIRVCVGTW 550 NVNGGKQFRS 560 IAFKNQTLTD 570 WLLDAPKLAG 580 IQEFQDKRSK 590 PTDIFAIGFE 600 EMVELNAGNI 610 VNASTTNQKL 620 WAVELQKTIS 630 RDNKYVLLAS 640 EQLVGVCLFV 650 FIRPQHAPFI 660 RDVAVDTVKT 670 GMGGATGNKG 680 AVAIRMLFHT 690 TSLCFVCSHF 700 AAGQSQVKER 710 NEDFVEIARK 720 LSFPMGRMLF 730 SHDYVFWCGD 740 FNYRIDLPNE 750 EVKELIRQQN 760 WDSLIAGDQL 770 INQKNAGQIF 780 RGFLEGKVTF 790 APTYKYDLFS 800 EDYDTSEKCR 810 TPAWTDRVLW 820 RRRKWPFDRS 830 AEDLDLLNAS 840 FQDESKILYT 850 WTPGTLLHYG 860 RAELKTSDHR 870 PVVALIDIDI 880 FEVEAEERQK 890 IYKEVIAVQG 900 PPDGTVLVSI 910 KSSAQENTFF 920 DDALIDELLQ 930 QFAHFGEVIL 940 IRFVEDKMWV 950 TFLEGSSALN 960 VLSLNGKELL 970 NRTITITLKS 980 PDWIKTLEEE 990 MSLEKISVTL 1000 PSSTSSTLLG 1010 EDAEVSADFD 1020 MEGDVDDYSA 1030 EVEELLPQHL 1040 QPSSSSGLGT 1050 SPSSSPRTSP 1060 CQSPTAPEYS 1070 APSLPIRPSR 1080 APSRTPGPLS 1090 SQGAPVDTQP 1100 AAQKESSQTI 1110 EPKRPPPPRP 1120 VAPPARPAPP 1130 QRPPPPSGAR 1140 SPAPARKEFG 1150 GVGAPPSPGV 1160 TRREMEAPKS 1170 PGTARKDNIG 1180 RNQPSPQAGL 1190 AGPGPSGYGA 1200 ARPTIPARAG 1210 VISAPQSQAR 1220 VSAGRLTPES 1230 QSKPLETSKG 1240 PAVLPEPLKP 1250 QAAFPPQPSL 1260 PTPAQKLQDP 1270 LVPIAAPMPP 1280 SIPQSNLETP 1290 PLPPPRSRSS 1300 QSLPSDSSPQ 1310 LQQEQPTGQQ 1320 VKINGACGVK 1330 QEPTLKSDPF 1340 EDLSLSVLAV 1350 SKAQPSAQIS 1360 PVLTPDPKML 1370 IQLPSASQSK 1380 VNSLSSVSCM 1390 LTMPPVPEQS 1400 KSQESVGSSA 1410 NPFPSLPTRN 1420 PFTDRTAAPG 1430 NPFRVQSQES 1440 EATSWLSKEE 1450 PVSNSPFPPL 1460 MPLSHDMSKP 1470 SSSLDGFEDN 1480 FDLQSQSTVK 1490 TSNPKGWVTF 1500 DEDEDFPTKG 1510 KSRSVYPDSL 1520 GNTAASFDDD 1530 WSKGTNVSFC 1540 VLPARRPPPP 1550 PPPVPLLPPG 1560 TTSSAGPSTT 1570 LSSKASPTLD FTER

Gene Ontology

Classification GO ID Description
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0098793 presynapse
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0097060 synaptic membrane
Cellular Component GO:0043195 terminal bouton
Cellular Component GO:0012506 vesicle membrane
Molecular Function GO:1990175 EH domain binding
Molecular Function GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
Molecular Function GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity
Molecular Function GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity
Molecular Function GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Molecular Function GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0017124 SH3 domain binding
Biological Process GO:1902634 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
Biological Process GO:0032957 inositol trisphosphate metabolic process
Biological Process GO:0007612 learning
Biological Process GO:0006836 neurotransmitter transport
Biological Process GO:0031161 phosphatidylinositol catabolic process
Biological Process GO:0046856 phosphatidylinositol dephosphorylation
Biological Process GO:0046488 phosphatidylinositol metabolic process
Biological Process GO:1904980 positive regulation of endosome organization
Biological Process GO:0014015 positive regulation of gliogenesis
Biological Process GO:0048260 positive regulation of receptor-mediated endocytosis
Biological Process GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
Biological Process GO:0034097 response to cytokine
Biological Process GO:0032526 response to retinoic acid
Biological Process GO:0048488 synaptic vesicle endocytosis
Biological Process GO:0016082 synaptic vesicle priming
Biological Process GO:0036465 synaptic vesicle recycling
Biological Process GO:0048489 synaptic vesicle transport
Biological Process GO:0016191 synaptic vesicle uncoating
Cellular Component GO:0030132 clathrin coat of coated pit
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0030117 membrane coat
Cellular Component GO:0098688 parallel fiber to Purkinje cell synapse

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.