Search Results

Overview

Uniprot IDQ62920
Protein NamePDZ and LIM domain protein 5
Gene NamePdlim5
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
101 AVQKGEPKEVVKPVP
105 GEPKEVVKPVPITSP
22 GFRLQGGKDFNMPLT
261 PTHSDASKKRLIEDT
296 ITGTEHLKESENDNA
346 LRSAAAFKPVGSTSV
354 PVGSTSVKSPSWQRP
410 AEHIPAGKRTPMCAH
584 KDKPLCKKHAHSVNF
89 QRASAAAKSEPVAVQ
97 SEPVAVQKGEPKEVV

Function

May play an important role in the heart development by scaffolding PKC to the Z-disk region (PubMed:20097676, PubMed:8940095). May play a role in the regulation of cardiomyocyte expansion (PubMed:20097676). Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1 (PubMed:20097676). Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons (PubMed:20097676). May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation (PubMed:19900557)

Protein Sequence

10 MSNYNVSLVG 20 PAPWGFRLQG 30 GKDFNMPLTI 40 SSLKDGGKAS 50 QAHVRIGDVV 60 LSIDGISAQG 70 MTHLEAQNKI 80 KACTGSLNMT 90 LQRASAAAKS 100 EPVAVQKGEP 110 KEVVKPVPIT 120 SPAVSKVTST 130 TNMAYNKVPR 140 PFGSVSSPKV 150 TSIPSPSSAF 160 TPAHAATSSH 170 ASPPPVAAVT 180 PPPLSASGLH 190 ASANPSAAQC 200 SSPPNTGKPA 210 VHVPRQPTVT 220 SVCSESAQEL 230 AEGQRRGSQG 240 DIKQQNGPPR 250 KHIVERNTEF 260 YHIPTHSDAS 270 KKRLIEDTED 280 WRPRTGTTQS 290 RSFRILAQIT 300 GTEHLKESEN 310 DNAKKANSTP 320 EPSQQSASPL 330 SAAESLESPG 340 SNRPVVAGLR 350 SAAAFKPVGS 360 TSVKSPSWQR 370 PNQAAPSTGR 380 ISNSASSSGT 390 GAPMKPAVGP 400 PQPSDQDTLV 410 QRAEHIPAGK 420 RTPMCAHCNQ 430 AIRGPFLVAL 440 GKSWHPEEFN 450 CAHCKNTMAY 460 IGFVEEKGAL 470 YCELCYEKFF 480 APECGRCQRK 490 ILGEVINALK 500 QTWHVSCFVC 510 VACGKPIRNN 520 VFHLEDGEPY 530 CETDYYALFG 540 TICRGCEFPI 550 EAGDMFLEAL 560 GSTWHDTCFV 570 CSVCCESLEG 580 QTFFSKKDKP 590 LCKKHAHSVN F

Gene Ontology

Classification GO ID Description
Biological Process GO:0007507 heart development
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031941 filamentous actin
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0098793 presynapse
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0042805 actinin binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0051371 muscle alpha-actinin binding
Molecular Function GO:0005080 protein kinase C binding
Molecular Function GO:0030159 signaling receptor complex adaptor activity
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0061049 cell growth involved in cardiac muscle cell development
Biological Process GO:0061061 muscle structure development
Biological Process GO:0061001 regulation of dendritic spine morphogenesis
Biological Process GO:0150052 regulation of postsynapse assembly
Biological Process GO:0051963 regulation of synapse assembly

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.